TY - JOUR
T1 - Impact of weight reduction on pericardial adipose tissue and cardiac structure in patients with atrial fibrillation
AU - Abed, Hany S.
AU - Nelson, Adam J.
AU - Richardson, James D.
AU - Worthley, Stephen G.
AU - Vincent, Andrew
AU - Wittert, Gary A.
AU - Leong, Darryl P.
N1 - Funding Information:
Dr Abed is supported by the Australian Postgraduate Award and an Earl Bakken Electrophysiology Scholarships from the University of Adelaide. Dr Leong is supported by the EJ Moran Campbell Award, McMaster University.
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Background Obesity and pericardial adipose tissue are independent risk factors for atrial fibrillation (AF) and adverse cardiac structural remodeling. The effect of weight reduction on pericardial adipose tissue and cardiac structure remains unknown. Methods We prospectively performed cardiac magnetic resonance imaging on 87 participants with AF undergoing either structured weight management (intervention) or general lifestyle advice (control). We measured pericardial adipose tissue, atrial and ventricular volumes, and myocardial mass at baseline and 12 months. Results In total, 69 participants underwent baseline and 12-month follow-up cardiac magnetic resonance imaging (intervention n = 36 and controls n = 33). From baseline to 12 months, weight loss (kg, mean [95% CI]) was greater in the intervention group from 101.5 kg (97.2-105.8 kg) to 86.5 kg (81.2-91.9 kg) as compared with controls from 102.6 kg (97.2-108.1 kg) to 98.7 kg (91.0-106.3 kg) (time-group interaction P <.001). The intervention group showed a reduction in left atrial volumes (mL) from 105.0 mL (98.9-111.1 mL) to 96.4 mL (91.6-101.1 mL), whereas the change in the control group was from 108.8 mL (99.6-117.9 mL) to 108.9 mL (99.8-118.0 mL) (time-group interaction P <.001). There was a decline in pericardial adipose tissue (cm3) from 140.9 cm3 (129.3-152.4 cm3) to 118.8 cm3 (108.1-129.6 cm3) and myocardial mass (g) from 137.6 g (128.1-147.2 g) to 123.1 g (114.5-131.7 g) in the intervention group, whereas the change in the control group was from 143.2 cm3 (124.6-161.7 cm3) to 147.2 cm3 (128.9-165.4 cm3) for pericardial adipose tissue and 138.3 g (124.8-151.8 g) to 140.7 g (127.4-154.1 g) for myocardial mass (both variables, time-group interaction P <.001). Conclusions Weight reduction results in favorable structural remodeling and a reduction in pericardial adipose tissue burden.
AB - Background Obesity and pericardial adipose tissue are independent risk factors for atrial fibrillation (AF) and adverse cardiac structural remodeling. The effect of weight reduction on pericardial adipose tissue and cardiac structure remains unknown. Methods We prospectively performed cardiac magnetic resonance imaging on 87 participants with AF undergoing either structured weight management (intervention) or general lifestyle advice (control). We measured pericardial adipose tissue, atrial and ventricular volumes, and myocardial mass at baseline and 12 months. Results In total, 69 participants underwent baseline and 12-month follow-up cardiac magnetic resonance imaging (intervention n = 36 and controls n = 33). From baseline to 12 months, weight loss (kg, mean [95% CI]) was greater in the intervention group from 101.5 kg (97.2-105.8 kg) to 86.5 kg (81.2-91.9 kg) as compared with controls from 102.6 kg (97.2-108.1 kg) to 98.7 kg (91.0-106.3 kg) (time-group interaction P <.001). The intervention group showed a reduction in left atrial volumes (mL) from 105.0 mL (98.9-111.1 mL) to 96.4 mL (91.6-101.1 mL), whereas the change in the control group was from 108.8 mL (99.6-117.9 mL) to 108.9 mL (99.8-118.0 mL) (time-group interaction P <.001). There was a decline in pericardial adipose tissue (cm3) from 140.9 cm3 (129.3-152.4 cm3) to 118.8 cm3 (108.1-129.6 cm3) and myocardial mass (g) from 137.6 g (128.1-147.2 g) to 123.1 g (114.5-131.7 g) in the intervention group, whereas the change in the control group was from 143.2 cm3 (124.6-161.7 cm3) to 147.2 cm3 (128.9-165.4 cm3) for pericardial adipose tissue and 138.3 g (124.8-151.8 g) to 140.7 g (127.4-154.1 g) for myocardial mass (both variables, time-group interaction P <.001). Conclusions Weight reduction results in favorable structural remodeling and a reduction in pericardial adipose tissue burden.
UR - http://www.scopus.com/inward/record.url?scp=84929274933&partnerID=8YFLogxK
U2 - 10.1016/j.ahj.2015.02.008
DO - 10.1016/j.ahj.2015.02.008
M3 - Article
C2 - 25965713
AN - SCOPUS:84929274933
VL - 169
SP - 655-662.e2
JO - American Heart Journal
JF - American Heart Journal
SN - 0002-8703
IS - 5
ER -