Improved radiosynthesis of the apoptosis marker 18F-ICMT11 including biological evaluation

Matthias Glaser, Julian Goggi, Graham Smith, Matthew Morrison, Sajinder K. Luthra, Edward Robins, Eric O. Aboagye

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)


We improved the specific radioactivity of the apoptosis imaging isatin derivative 18F-ICMT11. We then evaluated 18F-ICMT11 in EL4 tumor-bearing mice 24 h after treatment with etoposide/cyclophosphamide combination therapy. Dynamic PET imaging demonstrated increased uptake in the drug-treated (0.115 ± 0.011 SUV) compared to the vehicle-treated EL4 tumors (0.083 ± 0.008 SUV). This effect correlated to the observed increases in apoptotic index.

Original languageEnglish
Pages (from-to)6945-6949
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Issue number23
Publication statusPublished or Issued - 1 Dec 2011
Externally publishedYes


  • Apoptosis
  • Caspase
  • Click chemistry
  • Fluorine-18
  • Isatin
  • PET

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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