Improved radiosynthesis of the apoptosis marker 18F-ICMT11 including biological evaluation

Matthias Glaser; Julian Goggi; Graham Smith; Matthew Morrison; Sajinder K. Luthra; Edward Robins; Eric O. Aboagye

doi:10.1016/j.bmcl.2011.10.001

Improved radiosynthesis of the apoptosis marker ¹⁸F-ICMT11 including biological evaluation

Matthias Glaser, Julian Goggi, Graham Smith, Matthew Morrison, Sajinder K. Luthra, Edward Robins, Eric O. Aboagye

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

We improved the specific radioactivity of the apoptosis imaging isatin derivative ¹⁸F-ICMT11. We then evaluated ¹⁸F-ICMT11 in EL4 tumor-bearing mice 24 h after treatment with etoposide/cyclophosphamide combination therapy. Dynamic PET imaging demonstrated increased uptake in the drug-treated (0.115 ± 0.011 SUV) compared to the vehicle-treated EL4 tumors (0.083 ± 0.008 SUV). This effect correlated to the observed increases in apoptotic index.

Original language	English
Pages (from-to)	6945-6949
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	21
Issue number	23
DOIs	https://doi.org/10.1016/j.bmcl.2011.10.001
Publication status	Published or Issued - 1 Dec 2011
Externally published	Yes

Keywords

Apoptosis
Caspase
Click chemistry
Fluorine-18
Isatin
PET

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/j.bmcl.2011.10.001

Cite this

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title = "Improved radiosynthesis of the apoptosis marker 18F-ICMT11 including biological evaluation",

abstract = "We improved the specific radioactivity of the apoptosis imaging isatin derivative 18F-ICMT11. We then evaluated 18F-ICMT11 in EL4 tumor-bearing mice 24 h after treatment with etoposide/cyclophosphamide combination therapy. Dynamic PET imaging demonstrated increased uptake in the drug-treated (0.115 ± 0.011 SUV) compared to the vehicle-treated EL4 tumors (0.083 ± 0.008 SUV). This effect correlated to the observed increases in apoptotic index.",

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AU - Glaser, Matthias

AU - Goggi, Julian

AU - Smith, Graham

AU - Morrison, Matthew

AU - Luthra, Sajinder K.

AU - Robins, Edward

AU - Aboagye, Eric O.

PY - 2011/12/1

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KW - Apoptosis

KW - Caspase

KW - Click chemistry

KW - Fluorine-18

KW - Isatin

KW - PET

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