Indomethacin treatment of infantile cortical periostosis in twins

R. T.L. Couper, Andrew McPhee, L. Morris

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22 Citations (Scopus)


Twin girls presented with infantile cortical periostosis (Caffey's disease) at 2 and 3 weeks of age, respectively. This disorder initially involved their upper and lower limbs and resulted in fever, irritability and tenderness. X-rays showed extensive periosteal new bone formation. Multiple relapses occurred in the first year of life and during some of these relapses mandibular and clavicular involvement was noted. Prednisolone, 1 mg/kg per day, was used to treat relapses until 9 months of age. Indomethacin therapy at this age at a dose of 3 mg/kg per day allowed the cessation of prednisolone therapy and disease flares were thereafter infrequent and responsive to indomethacin.

Original languageEnglish
Pages (from-to)305-308
Number of pages4
JournalJournal of Paediatrics and Child Health
Issue number3
Publication statusPublished or Issued - 2001


  • Bone
  • Caffey's disease
  • Indomethacin
  • Infantile cortical periostosis
  • Prostaglandin synthetase inhibitors

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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