Induction of constitutive heat shock protein 73 mRNA in the dentate gyrus by seizures

Ma Li Wong, Susan R.B. Weiss, Philip W. Gold, Sonia Q. Doi, Sujit Banerjee, Julio Licinio, Rajnikant Lad, Robert M. Post, Mark A. Smith

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25 Citations (Scopus)


We examined the effects of generalized seizures on heat shock protein (hsp) mRNA induction in the rat brain using in situ hybridization. Seizures induced by electroconvulsive shock, electrical or cocaine kindling caused a selective induction of the constitutive hsp 73 gene in the dentate gyrus. In these seizure paradigms, not thought to induce widespread tissue damage, neither the heat-inducible hsp 72 gene nor a member of the hsp 90 family (hsp 84) were induced. Hsp 73 may play a role in the adaptation and/or in the maintainence of dentate granule cell integrity following seizures.

Original languageEnglish
Pages (from-to)19-25
Number of pages7
JournalMolecular Brain Research
Issue number1-2
Publication statusPublished or Issued - Mar 1992
Externally publishedYes


  • Cocaine
  • Dentate gyrus
  • Electroconvulsive seizure
  • Heat shock protein
  • Hippocampus
  • In situ hybridization
  • Kindling
  • mRNA

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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