Influence of ethnic background on left atrial markers of inflammation, endothelial function and tissue remodelling

Carlee D. Ruediger, Bobby John, Sathesh Kumar, Han S. Lim, Geetanjali Rangnekar, Kurt C. Roberts-Thomson, Glenn D. Young, David Chase, Prashanthan Sanders, Scott R. Willoughby

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2 Citations (Scopus)


Background: It has been suggested that ethnicity can make a significant difference to the likelihood of thromboembolic stroke related to atrial fibrillation. Ethnic differences have been shown to alter inflammatory and haemostatic factors; however, this may all be confounded by differences in cardiovascular risk factors between different ethnicity. The impact of different ethnicities on the thrombogenic profile is not known. The aim of this study was to investigate differences in markers of inflammation, endothelial function and tissue remodelling between Caucasian and Indian populations with supraventricular tachycardia (SVT). Methods: Patients with structurally normal hearts undergoing catheter ablation for SVT were studied. This study included 23 Australian (Caucasian) patients from the Royal Adelaide Hospital, Adelaide, Australia and 24 Indian (Indian) patients from the Christian Medical College, Vellore, India. Blood samples were collected from the femoral vein, and right and left atria. Blood samples were analysed for the markers of endothelial function (ADMA, ET-1), inflammation (CD40L, VCAM-1, ICAM-1), and tissue remodelling (MMP-9, TIMP-1) using ELISA. Results: The study populations were well matched for cardiovascular risk factors and the absence of structural heart disease. No difference in the echocardiographic measurements between the two ethnicities was found. In this context, there was no difference in markers of inflammation, endothelial function or tissue remodelling between the two SVT populations. Conclusion: Caucasian and Indian populations demonstrate similar inflammatory, endothelial function or tissue remodelling profiles. This study suggests a lack of an impact of different ethnicity in these populations in terms of thrombogenic risk.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalIndian Pacing and Electrophysiology Journal
Issue number1
Publication statusPublished or Issued - Jan 2018


  • Endothelial function
  • Ethnicity
  • Inflammation
  • Supraventricular tachycardia
  • Thrombogenesis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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