Influence of OprM expression on multiple antibiotic resistance in Pseudomonas aeruginosa

Kendy K.Y. Wong, Keith Poole, Naomasah Gotoh, Robert E.W. Hancock

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18 Citations (Scopus)

Abstract

MexA-MexB-OprM is an efflux system in Pseudomonas aeruginosa. OprM overproduced from the cloned gene was able to complement OprM-deficient mutants but did not alter the resistance of a wild-type P. aeruginosa strain to the different antimicrobial agents tested. This suggests that OprM cannot function by itself to efflux antibiotics, including β-lactams targeted to the periplasm.

Original languageEnglish
Pages (from-to)2009-2012
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume41
Issue number9
DOIs
Publication statusPublished or Issued - Sept 1997
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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