Influence of OprM expression on multiple antibiotic resistance in Pseudomonas aeruginosa

Kendy K.Y. Wong; Keith Poole; Naomasah Gotoh; Robert E.W. Hancock

doi:10.1128/aac.41.9.2009

Influence of OprM expression on multiple antibiotic resistance in Pseudomonas aeruginosa

Kendy K.Y. Wong, Keith Poole, Naomasah Gotoh, Robert E.W. Hancock

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

MexA-MexB-OprM is an efflux system in Pseudomonas aeruginosa. OprM overproduced from the cloned gene was able to complement OprM-deficient mutants but did not alter the resistance of a wild-type P. aeruginosa strain to the different antimicrobial agents tested. This suggests that OprM cannot function by itself to efflux antibiotics, including β-lactams targeted to the periplasm.

Original language	English
Pages (from-to)	2009-2012
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	41
Issue number	9
DOIs	https://doi.org/10.1128/aac.41.9.2009
Publication status	Published or Issued - Sept 1997
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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abstract = "MexA-MexB-OprM is an efflux system in Pseudomonas aeruginosa. OprM overproduced from the cloned gene was able to complement OprM-deficient mutants but did not alter the resistance of a wild-type P. aeruginosa strain to the different antimicrobial agents tested. This suggests that OprM cannot function by itself to efflux antibiotics, including β-lactams targeted to the periplasm.",

author = "Wong, {Kendy K.Y.} and Keith Poole and Naomasah Gotoh and Hancock, {Robert E.W.}",

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AU - Poole, Keith

AU - Gotoh, Naomasah

AU - Hancock, Robert E.W.

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AB - MexA-MexB-OprM is an efflux system in Pseudomonas aeruginosa. OprM overproduced from the cloned gene was able to complement OprM-deficient mutants but did not alter the resistance of a wild-type P. aeruginosa strain to the different antimicrobial agents tested. This suggests that OprM cannot function by itself to efflux antibiotics, including β-lactams targeted to the periplasm.

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JO - Antimicrobial Agents and Chemotherapy

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ER -

Influence of OprM expression on multiple antibiotic resistance in Pseudomonas aeruginosa

Abstract

ASJC Scopus subject areas

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