Insulin potentiating action of a peptide fraction from human urine

F. M. Ng; P. Z. Zimmet; G. Seiler; P. Taft; J. Bornstein

doi:10.2337/diab.23.12.950

Insulin potentiating action of a peptide fraction from human urine

F. M. Ng, P. Z. Zimmet, G. Seiler, P. Taft, J. Bornstein

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

An impure peptide preparation from human urine was shown to have similar biological effects in vitro and in vivo to synthetic peptides containing the human growth hormone sequence Leu Ser Arg Leu Phe Asp Asn Ala (residues 6-13). The urinary preparation potentiates the action of insulin in the isolated rat diaphragm and in rabbits and rats, but the latter animals are far more sensitive to its action. Species specificity is possibly a significant factor in determining dosage in future studies.

Original language	English
Pages (from-to)	950-956
Number of pages	7
Journal	Unknown Journal
Volume	23
Issue number	12
DOIs	https://doi.org/10.2337/diab.23.12.950
Publication status	Published or Issued - 1974
Externally published	Yes

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

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10.2337/diab.23.12.950

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AU - Zimmet, P. Z.

AU - Seiler, G.

AU - Taft, P.

AU - Bornstein, J.

PY - 1974

Y1 - 1974

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Insulin potentiating action of a peptide fraction from human urine

Abstract

ASJC Scopus subject areas

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