TY - JOUR
T1 - Is platinum-based chemotherapy with paclitaxel effective in optimally debulked patients with advanced ovarian cancer?
AU - Roovers, Jan Paul W.R.
AU - Sijmons, Edith A.
AU - Van Leeuwen, Jules H.Schagen
AU - Mol, Ben W.J.
AU - Witteveen, Petronella O.
AU - Slee, Peter H.Th J.
AU - Heintz, A. Peter M.
N1 - Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2001
Y1 - 2001
N2 - Objective: Suboptimally debulked patients with advanced ovarian cancer who are treated with a combination of cisplatin plus paclitaxel (TP therapy) have a better survival as compared to patients treated with a combination of cisplatin plus cyclophosphamide (CP therapy), but this advantage has not been demonstrated in optimally debulked patients. We performed a retrospective study to compare the effectiveness of TP therapy and CP therapy in optimally debulked patients. Study Design: From 1991 to 1996, 87 consecutive patients with advanced ovarian cancer treated in the University Hospital Utrecht and the St. Antonius Hospital were included in the study. Overall survival (OS) of patients treated with TP or CP were compared. Multivariable Cox-regression analysis was used to calculate a hazard rate ratio (HRR) for OS. Results: In the study period, 51 patients were treated with CP, and 36 patients were treated with TP. In the 18 patients with a tumorrest >2cm, there was a clear, but not statistically significant benefit from TP. In 69 patients with a tumorrest ≤2cm, life expectancy was not increased in patients treated with TP as compared to patients treated with CP (HRR 0.9 (95% CI 0.4-1.9)). Conclusion: We could not show that ovarian cancer patients with residual disease of ≤2cm who were treated with TP had better survival as compared to patients who were treated with CP. Taking into account the high costs of treatment with TP, a randomized trial comparing the effects of TP therapy and CP therapy in optimally debulked patients is warranted.
AB - Objective: Suboptimally debulked patients with advanced ovarian cancer who are treated with a combination of cisplatin plus paclitaxel (TP therapy) have a better survival as compared to patients treated with a combination of cisplatin plus cyclophosphamide (CP therapy), but this advantage has not been demonstrated in optimally debulked patients. We performed a retrospective study to compare the effectiveness of TP therapy and CP therapy in optimally debulked patients. Study Design: From 1991 to 1996, 87 consecutive patients with advanced ovarian cancer treated in the University Hospital Utrecht and the St. Antonius Hospital were included in the study. Overall survival (OS) of patients treated with TP or CP were compared. Multivariable Cox-regression analysis was used to calculate a hazard rate ratio (HRR) for OS. Results: In the study period, 51 patients were treated with CP, and 36 patients were treated with TP. In the 18 patients with a tumorrest >2cm, there was a clear, but not statistically significant benefit from TP. In 69 patients with a tumorrest ≤2cm, life expectancy was not increased in patients treated with TP as compared to patients treated with CP (HRR 0.9 (95% CI 0.4-1.9)). Conclusion: We could not show that ovarian cancer patients with residual disease of ≤2cm who were treated with TP had better survival as compared to patients who were treated with CP. Taking into account the high costs of treatment with TP, a randomized trial comparing the effects of TP therapy and CP therapy in optimally debulked patients is warranted.
KW - Ovarian cancer
KW - Paclitaxel
KW - Platinum-based chemotherapy
UR - http://www.scopus.com/inward/record.url?scp=0034929652&partnerID=8YFLogxK
U2 - 10.1016/S0301-2115(00)00502-9
DO - 10.1016/S0301-2115(00)00502-9
M3 - Article
C2 - 11435015
AN - SCOPUS:0034929652
SN - 0301-2115
VL - 97
SP - 80
EP - 84
JO - European Journal of Obstetrics and Gynecology and Reproductive Biology
JF - European Journal of Obstetrics and Gynecology and Reproductive Biology
IS - 1
ER -