Islet autoimmunity status in Asians with young-onset diabetes (12-40 years): Association with clinical characteristics, beta cell function and cardio-metabolic risk factors

A. C. Thai, V. Mohan, B. A.K. Khalid, C. S. Cockram, C. Y. Pan, P. Zimmet, J. P. Yeo, Zhu Xi Xing, Shi Hong Li, Lu Juming, Wan Nazaimoon Wan Mohamud, Ikram Shah Ismail, Noraini Nadior, G. R. Letchuman, S. Singaraveloo, Wan Mohamad Wan Bebakar, Rema Mohan, Soon Puay Cheow, Loh Keh Chuan, Lee Choon HornTavintharan Subramaniam, Chionh Siok Bee

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In this paper, the islet autoimmunity status and relation to clinical characteristics, beta cell function and cardio-metabolic risk factors in young-onset Asian diabetic patients are evaluated at baseline. The study population consisted of 912 patients (from China, India, Malaysia and Singapore) with age 12-40 years and diabetes duration <12 months. Autoantibodies to glutamic acid decarboxylase (GADA) and tyrosine phosphatase (IA-2A), beta cell function and cardio-metabolic risk parameters were assessed. Among our young patient cohort, 105 (11.5%) patients were GADA and/or IA-2A positives (Ab +ve). Ab +ve patients were younger, leaner, had more severe hyperglycaemia and lower beta cell function. The frequency of metabolic syndrome was significantly lower in Ab +ve patients (27%) compared to Ab -ve patients (54%). However, a substantial proportion of patients in both groups of patients had atherogenic dyslipidaemia, hypertension and albuminuria (micro or macro). In our study cohort, only one in 10 Asian youth with new-onset diabetes had evidence of islet autoimmunity. At least 60% of Ab +ve and 50% of Ab -ve patients demonstrated classical features of type 1 and type 2 diabetes respectively. Regardless of autoimmunity status, the cardio-metabolic risk factors, in particular atherogenic dyslipidaemia, hypertension and albuminuria were common in our patients with young-onset diabetes.

Original languageEnglish
Pages (from-to)224-230
Number of pages7
JournalDiabetes Research and Clinical Practice
Issue number2
Publication statusPublished or Issued - 1 May 2008


  • Beta cell function
  • GADA
  • IA-2A
  • Metabolic syndrome
  • Young Asians

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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