I.V. Bolus administration of subconvulsive doses of lignocaine to conscious sheep: Relationships between myocardial pharmacokinetics and pharmacodynamics

Y. F. Huang, R. N. Upton, W. B. Runciman

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20 Citations (Scopus)


We have studied relationships between the time-courses of lignocaine concentrations in arterial and coronary sinus blood and myocardial tissue, and negative inotropic effects on the myocardium, after i.v. bolus administration of 50-, 75- or 100-mg doses of lignocaine to conscious, chronically instrumented sheep. Peak arterial and coronary sinus blood lignocaine concentrations occurred 26-38 s before and 29-78 s after the maximum decreases in myocardial contractility, respectively. Peak myocardial concentrations occurred simultaneously with the maximum decreases in myocardial contractility, except for the 100-mg doses. Anticlockwise hysteresis occurred only between arterial blood lignocaine concentrations and the negative inotropic effect. It was concluded that, after short-term i.v. administration, only the myocardial concentrations of lignocaine were in pseudoequilibrium with the negative inotropic effects of the lignocaine on the myocardium. (Br. J. Anaesth. 1993; 70: 556-561).

Original languageEnglish
Pages (from-to)556-561
Number of pages6
JournalBritish Journal of Anaesthesia
Issue number5
Publication statusPublished or Issued - May 1993
Externally publishedYes


  • Anaesthetics, local: lignocaine.
  • Heart: myocardial drug concentration.
  • Pharmacodynamics. Pharmacokinetics

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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