TY - JOUR
T1 - I.V. Bolus administration of subconvulsive doses of lignocaine to conscious sheep
T2 - Relationships between myocardial pharmacokinetics and pharmacodynamics
AU - Huang, Y. F.
AU - Upton, R. N.
AU - Runciman, W. B.
N1 - Funding Information:
This study was supported by a grant from the National Heart Foundation of Australia. The authors thank Professor L. E. Mather for providing research facilities in the Department of Anaesthesia and Intensive Care of Flinders Medical Centre while those at the University of Adelaide were being refurbished. The authors also thank Dr J. P. Plummer for his statistical advice. Technical help from Mr K. Smart, Ms E. Henning and Ms C. Adcock is greatly appreciated.
PY - 1993/5
Y1 - 1993/5
N2 - We have studied relationships between the time-courses of lignocaine concentrations in arterial and coronary sinus blood and myocardial tissue, and negative inotropic effects on the myocardium, after i.v. bolus administration of 50-, 75- or 100-mg doses of lignocaine to conscious, chronically instrumented sheep. Peak arterial and coronary sinus blood lignocaine concentrations occurred 26-38 s before and 29-78 s after the maximum decreases in myocardial contractility, respectively. Peak myocardial concentrations occurred simultaneously with the maximum decreases in myocardial contractility, except for the 100-mg doses. Anticlockwise hysteresis occurred only between arterial blood lignocaine concentrations and the negative inotropic effect. It was concluded that, after short-term i.v. administration, only the myocardial concentrations of lignocaine were in pseudoequilibrium with the negative inotropic effects of the lignocaine on the myocardium. (Br. J. Anaesth. 1993; 70: 556-561).
AB - We have studied relationships between the time-courses of lignocaine concentrations in arterial and coronary sinus blood and myocardial tissue, and negative inotropic effects on the myocardium, after i.v. bolus administration of 50-, 75- or 100-mg doses of lignocaine to conscious, chronically instrumented sheep. Peak arterial and coronary sinus blood lignocaine concentrations occurred 26-38 s before and 29-78 s after the maximum decreases in myocardial contractility, respectively. Peak myocardial concentrations occurred simultaneously with the maximum decreases in myocardial contractility, except for the 100-mg doses. Anticlockwise hysteresis occurred only between arterial blood lignocaine concentrations and the negative inotropic effect. It was concluded that, after short-term i.v. administration, only the myocardial concentrations of lignocaine were in pseudoequilibrium with the negative inotropic effects of the lignocaine on the myocardium. (Br. J. Anaesth. 1993; 70: 556-561).
KW - Anaesthetics, local: lignocaine.
KW - Heart: myocardial drug concentration.
KW - Pharmacodynamics. Pharmacokinetics
UR - http://www.scopus.com/inward/record.url?scp=0027336339&partnerID=8YFLogxK
U2 - 10.1093/bja/70.5.556
DO - 10.1093/bja/70.5.556
M3 - Article
C2 - 8318331
AN - SCOPUS:0027336339
SN - 0007-0912
VL - 70
SP - 556
EP - 561
JO - British Journal of Anaesthesia
JF - British Journal of Anaesthesia
IS - 5
ER -