TY - JOUR
T1 - Lack of association of the CD14 promoter polymorphism -159C/T with Caucasian inflammatory bowel disease
AU - Peters, Kirsten E.
AU - O'Callaghan, Nathan J.
AU - Cavanaugh, Juleen A.
N1 - Funding Information:
This work was supported in part by a grant from the National Health and Medical Research Council (Australia). We gratefully acknowledge the participation of the patients and their families and the contribution of clinicians who aided in the collection of families.
PY - 2005/2
Y1 - 2005/2
N2 - Objective. The inflammatory bowel diseases (IBDs), including Crohn's disease (CD) and ulcerative colitis (UC), are multifactorial diseases resulting from a complex interaction of genetic and environmental factors. The recently described CARD15 and TNF-α risk alleles are believed to be contributors to disease by disrupting inflammatory pathways via impaired response to bacteria. Other bacterial receptors, such as CD14, may also have a role in disease. A promoter polymorphism (-159C/T) in CD14 has been implicated in IBD in a number of studies. Material and methods. We have analysed this CD14 promoter polymorphism in probands from 206 multiplex IBD families, 110 sporadic IBD individuals and 189 healthy controls from the Australian population, all of whom are Caucasian. Results. We could not replicate the described association between the CD14-159T allele and CD or UC, nor did we find any evidence for an interaction between the CARD15 or TNF-α risk alleles and the CD14-159Tallele. Conclusions. It is possible that the association seen in other studies may be due to population stratification or to the CD14 polymorphism being in linkage with the real disease-causing variant(s).
AB - Objective. The inflammatory bowel diseases (IBDs), including Crohn's disease (CD) and ulcerative colitis (UC), are multifactorial diseases resulting from a complex interaction of genetic and environmental factors. The recently described CARD15 and TNF-α risk alleles are believed to be contributors to disease by disrupting inflammatory pathways via impaired response to bacteria. Other bacterial receptors, such as CD14, may also have a role in disease. A promoter polymorphism (-159C/T) in CD14 has been implicated in IBD in a number of studies. Material and methods. We have analysed this CD14 promoter polymorphism in probands from 206 multiplex IBD families, 110 sporadic IBD individuals and 189 healthy controls from the Australian population, all of whom are Caucasian. Results. We could not replicate the described association between the CD14-159T allele and CD or UC, nor did we find any evidence for an interaction between the CARD15 or TNF-α risk alleles and the CD14-159Tallele. Conclusions. It is possible that the association seen in other studies may be due to population stratification or to the CD14 polymorphism being in linkage with the real disease-causing variant(s).
KW - CARD15
KW - CD14
KW - IBD
KW - NOD2
UR - http://www.scopus.com/inward/record.url?scp=13244250023&partnerID=8YFLogxK
U2 - 10.1080/00365520510011506
DO - 10.1080/00365520510011506
M3 - Article
C2 - 15764151
AN - SCOPUS:13244250023
SN - 0036-5521
VL - 40
SP - 194
EP - 197
JO - Scandinavian Journal of Gastroenterology
JF - Scandinavian Journal of Gastroenterology
IS - 2
ER -