LCPUFAs as Conditionally Essential Nutrients for Very Low Birth Weight and Low Birth Weight Infants. Metabolic, Functional, and Clinical Outcomes-How Much is Enough?

Maria Makrides, Ricardo Uauy

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)


Preterm infants are denied the rapid accumulation of docosahexaenoic acid (DHA) occurring during the third trimester in utero. The potential benefit of long-chain polyunsaturated fatty acids (LCPUFAs) has generated interest over the last 3 decades. Early intervention trials assessed the effects of supplementing infant formulas lacking DHA with concentrations equivalent to LCPUFA in milk of women from Westernized societies, leading to the inclusion of LCPUFA by the year 2000. Recently attention has been on determining the optimal dose of DHA and on whether there is in advantage in matching the higher doses of late pregnancy.

Original languageEnglish
Pages (from-to)451-461
Number of pages11
JournalClinics in Perinatology
Issue number2
Publication statusPublished or Issued - Jun 2014


  • Development
  • Low birth weight infants
  • Preterm
  • Randomized controlled trials
  • Very low birth weight infants

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

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