Leukemia in gastrointestinal organs as cause of treatment failure: 378 cases analyzed

Isabel Cunningham, Daniel Worthley

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Leukemia growing as tumors in gastrointestinal organs is an under-investigated cause of treatment failure and death. These present with symptoms often mistaken for common toxicities but may grow large before symptoms. To synthesize experience available only in case reports, 378 were analyzed. Invasive and metastatic behavior typical of solid GI tumors was revealed even when marrow was uninvolved. Within 3 months of diagnosis, 33% had died, 47% within 1 year. Survivals of 4 to 18 years after involvement suggest cure is possible. Evidence is presented that combined local and systemic therapy has successfully treated GI leukemic tumors when identified early.

Original languageEnglish
Pages (from-to)1327-1336
Number of pages10
JournalAmerican Journal of Hematology
Volume93
Issue number11
DOIs
Publication statusPublished or Issued - Nov 2018

ASJC Scopus subject areas

  • Hematology

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