Lifetime physical activity and the risk of non-Hodgkin lymphoma

Terry Boyle, Richard P. Gallagher, Randy D. Gascoyne, Joseph M. Connors, Nhu D. Le, John J. Spinelli

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11 Citations (Scopus)


Research regarding the association between physical activity and the risk of non-Hodgkin lymphoma (NHL) is limited and inconsistent, and few studies have investigated whether the intensity and timing of physical activity influence the association. A case-control study of NHL was conducted in British Columbia, Canada, in 2000 to 2004. Data were collected on various NHL risk factors, including moderate-intensity and vigorous-intensity physical activity performed over the lifetime. Logistic regression was used to estimate the association between physical activity and the risk of NHL. This analysis included 818 controls and 749 cases. Lifetime vigorousintensity physical activity was inversely associated with NHL risk. Participants in the second, third, and fourth quartiles of lifetime vigorous-intensity physical activity had an approximately 25% to 30% lower risk of NHL than those in the lowest quartile [adjusted odds ratios, 0.69 (95% confidence interval [CI], 0.52-0.93); 0.68 (95% CI, 0.50-0.92); and 0.75 (95% CI, 0.55-1.01), respectively]. No consistent associations were observed for total or moderateintensity physical activity. There were no apparent age periods in which physical activity appeared to confer a greater risk reduction. In this study, we found that lifetime vigorous-intensity physical activity was associated with a significantly reduced risk of NHL. Given this finding, more research on physical activity intensity and timing in relation to NHL risk is warranted.

Original languageEnglish
Pages (from-to)873-877
Number of pages5
JournalCancer Epidemiology Biomarkers and Prevention
Issue number5
Publication statusPublished or Issued - 1 May 2015
Externally publishedYes

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

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