Lipid abnormalities predict progression of renal disease in patients with type 1 diabetes

N. Tolonen, C. Forsblom, L. Thorn, J. Wadén, M. Rosengård-Bärlund, M. Saraheimo, M. Feodoroff, V. P. Mäkinen, D. Gordin, M. R. Taskinen, P. H. Groop

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72 Citations (Scopus)


Aims/hypothesis: We studied the impact of baseline lipid variables on the progression of renal disease in a large nationwide prospective cohort of patients with type 1 diabetes. Methods: A total of 2,304 adult patients with type 1 diabetes and available lipid profiles participating in the Finnish Diabetic Nephropathy Study (FinnDiane) were evaluated. Data on progression of renal disease were verified from medical files and patients were followed for 5.4±2.0 (mean ± SD) years. Results: High triacylglycerol, apolipoprotein (Apo) B, ApoA-II and HDL3-cholesterol concentrations predicted incident microalbuminuria. Progression to macroalbuminuria was predicted by high triacylglycerol and ApoB. When AER was entered into the model, triacylglycerol was no longer an independent predictor, but when patients with normal AER and microalbuminuria at baseline were pooled, triacylglycerol, HbA1c, male sex and AER were all independent predictors of renal disease. High total cholesterol, LDL-cholesterol, non-HDL-cholesterol and triacylglycerol as well as low HDL-cholesterol, HDL2-cholesterol, ApoA-I and ApoA-II concentrations were predictive of progression to end-stage renal disease. However, when estimated GFR was entered into the model, only total cholesterol remained an independent predictor of progression. Conclusions/interpretation: Lipid abnormalities, particularly high triacylglycerol concentrations, increase the risk of progression of renal disease.

Original languageEnglish
Pages (from-to)2522-2530
Number of pages9
Issue number12
Publication statusPublished or Issued - Dec 2009
Externally publishedYes


  • Albumin excretion rate
  • Albuminuria
  • Apolipoprotein
  • Cholesterol
  • Diabetic nephropathy
  • Estimated GFR
  • Lipid profile
  • Renal disease
  • Triacylglycerol
  • Type 1 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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