TY - JOUR
T1 - Long-term effects of weight loss with a very-low carbohydrate, low saturated fat diet on flow mediated dilatation in patients with type 2 diabetes
T2 - A randomised controlled trial
AU - Wycherley, Thomas P.
AU - Thompson, Campbell H.
AU - Buckley, Jonathan D.
AU - Luscombe-Marsh, Natalie D.
AU - Noakes, Manny
AU - Wittert, Gary A.
AU - Brinkworth, Grant D.
N1 - Publisher Copyright:
© 2016 Elsevier Ireland Ltd
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Background and aims Very-low carbohydrate diets can improve glycaemic control in patients with type 2 diabetes (T2DM). However, compared to traditional higher carbohydrate, low fat (HighCHO) diets, they have been associated with impaired endothelial function (measured by flow mediated dilatation [FMD]) that is possibly related to saturated fat. This study aimed to examine the effects of a 12-month hypocaloric very-low carbohydrate, low saturated fat (LowCHO) diet compared to an isocaloric HighCHO diet. Methods One hundred and fifteen obese patients with T2DM (age:58.4 ± 0.7 [SEM] yr, BMI:34.6 ± 0.4 kg/m2, HbA1c:7.33 [56.3 mmol/mol] ± 0.10%) were randomised to consume an energy restricted LowCHO diet (Carb:Pro:Fat:Sat-Fat 14:28:58: < 10% energy; n = 58) or isocaloric HighCHO diet (53:17:30: < 10%; n = 57) whilst undertaking exercise (60 min, 3/wk). Bodyweight, HbA1c and FMD were assessed. Results Seventy eight participants completed the intervention (LowCHO = 41, HighCHO = 37). Both groups experienced similar reductions in weight and HbA1c (−10.6 ± 0.7 kg, −1.05 ± 0.10%; p < 0.001 time, p ≥ 0.48 time × diet). FMD did not change (p = 0.11 time, p = 0.20 time × diet). Conclusions In patients with obesity and T2DM, HighCHO diet and LowCHO diet have similar effects on endothelial function.
AB - Background and aims Very-low carbohydrate diets can improve glycaemic control in patients with type 2 diabetes (T2DM). However, compared to traditional higher carbohydrate, low fat (HighCHO) diets, they have been associated with impaired endothelial function (measured by flow mediated dilatation [FMD]) that is possibly related to saturated fat. This study aimed to examine the effects of a 12-month hypocaloric very-low carbohydrate, low saturated fat (LowCHO) diet compared to an isocaloric HighCHO diet. Methods One hundred and fifteen obese patients with T2DM (age:58.4 ± 0.7 [SEM] yr, BMI:34.6 ± 0.4 kg/m2, HbA1c:7.33 [56.3 mmol/mol] ± 0.10%) were randomised to consume an energy restricted LowCHO diet (Carb:Pro:Fat:Sat-Fat 14:28:58: < 10% energy; n = 58) or isocaloric HighCHO diet (53:17:30: < 10%; n = 57) whilst undertaking exercise (60 min, 3/wk). Bodyweight, HbA1c and FMD were assessed. Results Seventy eight participants completed the intervention (LowCHO = 41, HighCHO = 37). Both groups experienced similar reductions in weight and HbA1c (−10.6 ± 0.7 kg, −1.05 ± 0.10%; p < 0.001 time, p ≥ 0.48 time × diet). FMD did not change (p = 0.11 time, p = 0.20 time × diet). Conclusions In patients with obesity and T2DM, HighCHO diet and LowCHO diet have similar effects on endothelial function.
KW - Cardiovascular disease risk
KW - Diet composition
KW - Endothelial function
KW - Weight loss
UR - https://www.scopus.com/pages/publications/84980037387
U2 - 10.1016/j.atherosclerosis.2016.07.908
DO - 10.1016/j.atherosclerosis.2016.07.908
M3 - Article
C2 - 27494448
AN - SCOPUS:84980037387
SN - 0021-9150
VL - 252
SP - 28
EP - 31
JO - Atherosclerosis
JF - Atherosclerosis
ER -