TY - JOUR
T1 - Magnetic resonance-derived circumferential strain provides a superior and incremental assessment of improvement in contractile function in patients early after ST-segment elevation myocardial infarction
AU - Wong, Dennis T L
AU - Leong, Darryl P.
AU - Weightman, Michael J.
AU - Richardson, James D.
AU - Dundon, Benjamin K.
AU - Psaltis, Peter J.
AU - Leung, Michael C H
AU - Meredith, Ian T.
AU - Worthley, Matthew I.
AU - Worthley, Stephen G.
N1 - Funding Information:
DW is supported by a NHMRC and NHF Post Graduate Scholarship. DL is supported by a NHMRC and NHF Post-Doctoral Fellowship. JDR is supported by an International Postgraduate Research Scholarship and Australian Postgraduate Award (University of Adelaide). PJP is supported by an NHMRC Post-Doctoral Biomedical Research Scholarship. MIW is supported by an SA Health Practitioner Fellowship.
PY - 2014/6
Y1 - 2014/6
N2 - Background: We evaluate whether circumferential strain derived from grid-tagged CMR is a better method for assessing improvement in segmental contractile function after STEMI compared to late gadolinium enhancement (LGE). Methods: STEMI patients post primary PCI underwent baseline CMR (day 3) and follow-up (day 90). Cine, grid-tagged and LGE images were acquired. Baseline LGE infarct hyperenhancement was categorised as ≤25%, 26-50%, 51-75% and >75% hyperenhancement. The segmental baseline circumferential strain (CS) and circumferential strain rate (CSR) were calculated from grid-tagged images. Segments demonstrating an improvement in wall motion of ≥1 grade compared to baseline were regarded as having improved segmental contractile-function. Results: Forty-five patients (aged 58±12 years) and 179 infarct segments were analysed. A baseline CS cutoff of -5% had sensitivity of 89%and specificity of 70%for detection of improvement in segmental-contractile-function. On receiver-operating characteristic analysis for predicting improvement in contractile function, AUC for baseline CS (0.82) compared favourably to LGE hyperenhancement (0.68), MVO (0.67) and baseline-CSR (0.74). On comparison of AUCs, baseline CS was superior to LGE hyperenhancement and MVO in predicting improvement in contractile function (P<0.001). On multivariate-analysis, baseline CS was the independent predictor of improvement in segmental contractile function (P<0.001). Conclusion: Grid-tagged CMR-derived baseline CS is a superior predictor of improvement in segmental contractile function, providing incremental value when added to LGE hyperenhancement and MVO following STEMI. Key points: • Baseline CS predicts contractile function recovery better than LGE and MVO following STEMI • Baseline CS predicts contractile function recovery better than baseline CSR following STEMI • Baseline CS provides incremental value to LGE and MVO following STEMI
AB - Background: We evaluate whether circumferential strain derived from grid-tagged CMR is a better method for assessing improvement in segmental contractile function after STEMI compared to late gadolinium enhancement (LGE). Methods: STEMI patients post primary PCI underwent baseline CMR (day 3) and follow-up (day 90). Cine, grid-tagged and LGE images were acquired. Baseline LGE infarct hyperenhancement was categorised as ≤25%, 26-50%, 51-75% and >75% hyperenhancement. The segmental baseline circumferential strain (CS) and circumferential strain rate (CSR) were calculated from grid-tagged images. Segments demonstrating an improvement in wall motion of ≥1 grade compared to baseline were regarded as having improved segmental contractile-function. Results: Forty-five patients (aged 58±12 years) and 179 infarct segments were analysed. A baseline CS cutoff of -5% had sensitivity of 89%and specificity of 70%for detection of improvement in segmental-contractile-function. On receiver-operating characteristic analysis for predicting improvement in contractile function, AUC for baseline CS (0.82) compared favourably to LGE hyperenhancement (0.68), MVO (0.67) and baseline-CSR (0.74). On comparison of AUCs, baseline CS was superior to LGE hyperenhancement and MVO in predicting improvement in contractile function (P<0.001). On multivariate-analysis, baseline CS was the independent predictor of improvement in segmental contractile function (P<0.001). Conclusion: Grid-tagged CMR-derived baseline CS is a superior predictor of improvement in segmental contractile function, providing incremental value when added to LGE hyperenhancement and MVO following STEMI. Key points: • Baseline CS predicts contractile function recovery better than LGE and MVO following STEMI • Baseline CS predicts contractile function recovery better than baseline CSR following STEMI • Baseline CS provides incremental value to LGE and MVO following STEMI
KW - Circumferential strain
KW - Late gadoliniumenhancement
KW - Magnetic resonance imaging
KW - Myocardial viability
KW - Myocardialgrid tagging
UR - http://www.scopus.com/inward/record.url?scp=84901616074&partnerID=8YFLogxK
U2 - 10.1007/s00330-014-3137-6
DO - 10.1007/s00330-014-3137-6
M3 - Article
C2 - 24723232
AN - SCOPUS:84901616074
VL - 24
SP - 1219
EP - 1228
JO - European Radiology
JF - European Radiology
SN - 0938-7994
IS - 6
ER -