Magnetic resonance-derived circumferential strain provides a superior and incremental assessment of improvement in contractile function in patients early after ST-segment elevation myocardial infarction

Dennis T.L. Wong, Darryl P. Leong, Michael J. Weightman, James D. Richardson, Benjamin K. Dundon, Peter J. Psaltis, Michael C.H. Leung, Ian T. Meredith, Matthew I. Worthley, Stephen G. Worthley

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


Background: We evaluate whether circumferential strain derived from grid-tagged CMR is a better method for assessing improvement in segmental contractile function after STEMI compared to late gadolinium enhancement (LGE). Methods: STEMI patients post primary PCI underwent baseline CMR (day 3) and follow-up (day 90). Cine, grid-tagged and LGE images were acquired. Baseline LGE infarct hyperenhancement was categorised as ≤25%, 26-50%, 51-75% and >75% hyperenhancement. The segmental baseline circumferential strain (CS) and circumferential strain rate (CSR) were calculated from grid-tagged images. Segments demonstrating an improvement in wall motion of ≥1 grade compared to baseline were regarded as having improved segmental contractile-function. Results: Forty-five patients (aged 58±12 years) and 179 infarct segments were analysed. A baseline CS cutoff of -5% had sensitivity of 89%and specificity of 70%for detection of improvement in segmental-contractile-function. On receiver-operating characteristic analysis for predicting improvement in contractile function, AUC for baseline CS (0.82) compared favourably to LGE hyperenhancement (0.68), MVO (0.67) and baseline-CSR (0.74). On comparison of AUCs, baseline CS was superior to LGE hyperenhancement and MVO in predicting improvement in contractile function (P<0.001). On multivariate-analysis, baseline CS was the independent predictor of improvement in segmental contractile function (P<0.001). Conclusion: Grid-tagged CMR-derived baseline CS is a superior predictor of improvement in segmental contractile function, providing incremental value when added to LGE hyperenhancement and MVO following STEMI. Key points: • Baseline CS predicts contractile function recovery better than LGE and MVO following STEMI • Baseline CS predicts contractile function recovery better than baseline CSR following STEMI • Baseline CS provides incremental value to LGE and MVO following STEMI

Original languageEnglish
Pages (from-to)1219-1228
Number of pages10
JournalEuropean Radiology
Issue number6
Publication statusPublished or Issued - Jun 2014


  • Circumferential strain
  • Late gadoliniumenhancement
  • Magnetic resonance imaging
  • Myocardial viability
  • Myocardialgrid tagging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this