Management of Mucositis During Chemotherapy: From Pathophysiology to Pragmatic Therapeutics

Ysabella Z.A. Van Sebille; Romany Stansborough; Hannah R. Wardill; Emma Bateman; Rachel J. Gibson; Dorothy M. Keefe

doi:10.1007/s11912-015-0474-9

Management of Mucositis During Chemotherapy: From Pathophysiology to Pragmatic Therapeutics

Ysabella Z.A. Van Sebille, Romany Stansborough, Hannah R. Wardill, Emma Bateman, Rachel J. Gibson, Dorothy M. Keefe

Research output: Contribution to journal › Review article › peer-review

68 Citations (Scopus)

Abstract

Chemotherapy-induced mucositis is a common condition caused by the breakdown of the mucosal barrier. Symptoms can include pain, vomiting and diarrhoea, which can often necessitate chemotherapy treatment breaks or dose reductions, thus compromising survival outcomes. Despite the significant impact of mucositis, there are currently limited clinically effective pharmacological therapies for the pathology. New emerging areas of research have been proposed to play key roles in the development of mucositis, providing rationale for potential new therapeutics for the prevention, treatment or management of chemotherapy-induced mucositis. This review aims to address these new areas of research and to comment on the therapeutics arising from them.

Original language	English
Article number	50
Journal	Current Oncology Reports
Volume	17
Issue number	11
DOIs	https://doi.org/10.1007/s11912-015-0474-9
Publication status	Published or Issued - 25 Nov 2015
Externally published	Yes

Keywords

Analgesics
Antimicrobials
Antioxidants
Benzydamine hydrochloride (HCl)
Cancer side effects
Chemotherapy-induced gut toxicity
Coating agents
Mucositis
Mucositis treatment
Palifermin
Probiotics
R-spondin1
Toxicity
Zinc sulphate

ASJC Scopus subject areas

Oncology

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10.1007/s11912-015-0474-9

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title = "Management of Mucositis During Chemotherapy: From Pathophysiology to Pragmatic Therapeutics",

abstract = "Chemotherapy-induced mucositis is a common condition caused by the breakdown of the mucosal barrier. Symptoms can include pain, vomiting and diarrhoea, which can often necessitate chemotherapy treatment breaks or dose reductions, thus compromising survival outcomes. Despite the significant impact of mucositis, there are currently limited clinically effective pharmacological therapies for the pathology. New emerging areas of research have been proposed to play key roles in the development of mucositis, providing rationale for potential new therapeutics for the prevention, treatment or management of chemotherapy-induced mucositis. This review aims to address these new areas of research and to comment on the therapeutics arising from them.",

keywords = "Analgesics, Antimicrobials, Antioxidants, Benzydamine hydrochloride (HCl), Cancer side effects, Chemotherapy-induced gut toxicity, Coating agents, Mucositis, Mucositis treatment, Palifermin, Probiotics, R-spondin1, Toxicity, Zinc sulphate",

author = "{Van Sebille}, {Ysabella Z.A.} and Romany Stansborough and Wardill, {Hannah R.} and Emma Bateman and Gibson, {Rachel J.} and Keefe, {Dorothy M.}",

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doi = "10.1007/s11912-015-0474-9",

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T2 - From Pathophysiology to Pragmatic Therapeutics

AU - Van Sebille, Ysabella Z.A.

AU - Stansborough, Romany

AU - Wardill, Hannah R.

AU - Bateman, Emma

AU - Gibson, Rachel J.

AU - Keefe, Dorothy M.

PY - 2015/11/25

Y1 - 2015/11/25

N2 - Chemotherapy-induced mucositis is a common condition caused by the breakdown of the mucosal barrier. Symptoms can include pain, vomiting and diarrhoea, which can often necessitate chemotherapy treatment breaks or dose reductions, thus compromising survival outcomes. Despite the significant impact of mucositis, there are currently limited clinically effective pharmacological therapies for the pathology. New emerging areas of research have been proposed to play key roles in the development of mucositis, providing rationale for potential new therapeutics for the prevention, treatment or management of chemotherapy-induced mucositis. This review aims to address these new areas of research and to comment on the therapeutics arising from them.

AB - Chemotherapy-induced mucositis is a common condition caused by the breakdown of the mucosal barrier. Symptoms can include pain, vomiting and diarrhoea, which can often necessitate chemotherapy treatment breaks or dose reductions, thus compromising survival outcomes. Despite the significant impact of mucositis, there are currently limited clinically effective pharmacological therapies for the pathology. New emerging areas of research have been proposed to play key roles in the development of mucositis, providing rationale for potential new therapeutics for the prevention, treatment or management of chemotherapy-induced mucositis. This review aims to address these new areas of research and to comment on the therapeutics arising from them.

KW - Analgesics

KW - Antimicrobials

KW - Antioxidants

KW - Benzydamine hydrochloride (HCl)

KW - Cancer side effects

KW - Chemotherapy-induced gut toxicity

KW - Coating agents

KW - Mucositis

KW - Mucositis treatment

KW - Palifermin

KW - Probiotics

KW - R-spondin1

KW - Toxicity

KW - Zinc sulphate

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ER -

Management of Mucositis During Chemotherapy: From Pathophysiology to Pragmatic Therapeutics

Abstract

Keywords

ASJC Scopus subject areas

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