TY - JOUR
T1 - Maternal vitamin D3 supplementation at 50 mg/d protects against low serum 25-hydroxyvitamin D in infants at 8 wk of age
T2 - A randomized controlled trial of 3 doses of vitamin D beginning in gestation and continued in lactation
AU - March, Kaitlin M.
AU - Chen, Nancy N.
AU - Karakochuk, Crystal D.
AU - Shand, Antonia W.
AU - Innis, Sheila M.
AU - Von Dadelszen, Peter
AU - Barr, Susan I.
AU - Lyon, Michael R.
AU - Whiting, Susan J.
AU - Weiler, Hope A.
AU - Green, Tim J.
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Background: Vitamin D supplementation is recommended for breastfed infants. Maternal supplementation beginning in gestation is a potential alternative, but its efficacy in maintaining infant 25-hydroxyvitamin D [25(OH)D] concentration after birth is unknown. Objectives: We determined the effect of 3 doses of maternal vitamin D supplementation beginning in gestation and continued in lactation on infant serum 25(OH)D and compared the prevalence of infant serum 25(OH)D cutoffs (.30, >40, >50, and >75 nmol/L) by dose at 8 wk of age. Design: Pregnant women (n = 226) were randomly allocated to receive 10, 25, or 50 mg vitamin D3/d from 13 to 24 wk of gestation until 8 wk postpartum, with no infant supplementation. Mother and infant blood was collected at 8 wk postpartum. Results: At 8 wk postpartum, mean [nmol/L (95% CI)] infant 25(OH)D at 8 wk was higher in the 50-μg/d [75 (67, 83)] than in the 25-μg/d [52 (45, 58)] or 10-μg/d [45 (38, 52)] vitamin D groups (P < 0.05). Fewer infants born to mothers in the 50-μg/d group had a 25(OH)D concentration <30 nmol/L (indicative of deficiency) than infants in the 25- and 10-μg/d groups, respectively (2% compared with 16% and 43%; P < 0.05). Fewer than 15% of infants in the 10-or 25-μg/d groups achieved a 25(OH)D concentration >75 nmol/L compared with 44% in the 50-mg/d group (P < 0.05). Almost all infants (w98%, n = 44) born to mothers in the 50-μg/d group achieved a 25(OH)D concentration >30 nmol/L. At 8 wk postpartum, mean maternal 25(OH)D concentration was higher in the 50-μg/d [88 (84, 91)] than in the 25-μg/d [78 (74, 81)] or 10-μg/d [69 (66, 73)] groups (P < 0.05). Conclusions: Maternal supplementation beginning in gestation with 50 μg vitamin D3/d protects 98% of unsupplemented breastfed infants against 25(OH)D deficiency (,30 nmol/L) to at least 8 wk, whereas 10 or 25 mg vitamin D/d protects only 57% and 84% of infants, respectively.
AB - Background: Vitamin D supplementation is recommended for breastfed infants. Maternal supplementation beginning in gestation is a potential alternative, but its efficacy in maintaining infant 25-hydroxyvitamin D [25(OH)D] concentration after birth is unknown. Objectives: We determined the effect of 3 doses of maternal vitamin D supplementation beginning in gestation and continued in lactation on infant serum 25(OH)D and compared the prevalence of infant serum 25(OH)D cutoffs (.30, >40, >50, and >75 nmol/L) by dose at 8 wk of age. Design: Pregnant women (n = 226) were randomly allocated to receive 10, 25, or 50 mg vitamin D3/d from 13 to 24 wk of gestation until 8 wk postpartum, with no infant supplementation. Mother and infant blood was collected at 8 wk postpartum. Results: At 8 wk postpartum, mean [nmol/L (95% CI)] infant 25(OH)D at 8 wk was higher in the 50-μg/d [75 (67, 83)] than in the 25-μg/d [52 (45, 58)] or 10-μg/d [45 (38, 52)] vitamin D groups (P < 0.05). Fewer infants born to mothers in the 50-μg/d group had a 25(OH)D concentration <30 nmol/L (indicative of deficiency) than infants in the 25- and 10-μg/d groups, respectively (2% compared with 16% and 43%; P < 0.05). Fewer than 15% of infants in the 10-or 25-μg/d groups achieved a 25(OH)D concentration >75 nmol/L compared with 44% in the 50-mg/d group (P < 0.05). Almost all infants (w98%, n = 44) born to mothers in the 50-μg/d group achieved a 25(OH)D concentration >30 nmol/L. At 8 wk postpartum, mean maternal 25(OH)D concentration was higher in the 50-μg/d [88 (84, 91)] than in the 25-μg/d [78 (74, 81)] or 10-μg/d [69 (66, 73)] groups (P < 0.05). Conclusions: Maternal supplementation beginning in gestation with 50 μg vitamin D3/d protects 98% of unsupplemented breastfed infants against 25(OH)D deficiency (,30 nmol/L) to at least 8 wk, whereas 10 or 25 mg vitamin D/d protects only 57% and 84% of infants, respectively.
KW - 25(OH)D
KW - Infant
KW - Lactation
KW - Postpartum
KW - Pregnancy
KW - Supplement
KW - Vitamin D
UR - http://www.scopus.com/inward/record.url?scp=84938683147&partnerID=8YFLogxK
U2 - 10.3945/ajcn.114.106385
DO - 10.3945/ajcn.114.106385
M3 - Article
C2 - 26156737
AN - SCOPUS:84938683147
SN - 0002-9165
VL - 102
SP - 402
EP - 410
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - 2
ER -