Mesenchymal stem cell-mediated functional tooth regeneration in Swine

Wataru Sonoyama; Yi Liu; Dianji Fang; Takayoshi Yamaza; Byoung Moo Seo; Chunmei Zhang; He Liu; Stan Gronthos; Cun Yu Wang; Songtao Shi; Songlin Wang

doi:10.1371/journal.pone.0000079

Mesenchymal stem cell-mediated functional tooth regeneration in Swine

Wataru Sonoyama, Yi Liu, Dianji Fang, Takayoshi Yamaza, Byoung Moo Seo, Chunmei Zhang, He Liu, Stan Gronthos, Cun Yu Wang, Songtao Shi, Songlin Wang

Blood Cancer Program

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Abstract

Mesenchymal stem cell-mediated tissue regeneration is a promising approach for regenerative medicine for a wide range of applications. Here we report a new population of stem cells isolated from the root apical papilla of human teeth (SCAP, stem cells from apical papilla). Using a minipig model, we transplanted both human SCAP and periodontal ligament stem cells (PDLSCs) to generate a root/periodontal complex capable of supporting a porcelain crown, resulting in normal tooth function. This work integrates a stem cell-mediated tissue regeneration strategy, engineered materials for structure, and current dental crown technologies. This hybridized tissue engineering approach led to recovery of tooth strength and appearance.

Original language	English
Article number	e79
Journal	PloS one
Volume	1
Issue number	1
DOIs	https://doi.org/10.1371/journal.pone.0000079
Publication status	Published or Issued - 20 Dec 2006

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title = "Mesenchymal stem cell-mediated functional tooth regeneration in Swine",

abstract = "Mesenchymal stem cell-mediated tissue regeneration is a promising approach for regenerative medicine for a wide range of applications. Here we report a new population of stem cells isolated from the root apical papilla of human teeth (SCAP, stem cells from apical papilla). Using a minipig model, we transplanted both human SCAP and periodontal ligament stem cells (PDLSCs) to generate a root/periodontal complex capable of supporting a porcelain crown, resulting in normal tooth function. This work integrates a stem cell-mediated tissue regeneration strategy, engineered materials for structure, and current dental crown technologies. This hybridized tissue engineering approach led to recovery of tooth strength and appearance.",

author = "Wataru Sonoyama and Yi Liu and Dianji Fang and Takayoshi Yamaza and Seo, {Byoung Moo} and Chunmei Zhang and He Liu and Stan Gronthos and Wang, {Cun Yu} and Songtao Shi and Songlin Wang",

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AU - Sonoyama, Wataru

AU - Liu, Yi

AU - Fang, Dianji

AU - Yamaza, Takayoshi

AU - Seo, Byoung Moo

AU - Zhang, Chunmei

AU - Liu, He

AU - Gronthos, Stan

AU - Wang, Cun Yu

AU - Shi, Songtao

AU - Wang, Songlin

PY - 2006/12/20

Y1 - 2006/12/20

N2 - Mesenchymal stem cell-mediated tissue regeneration is a promising approach for regenerative medicine for a wide range of applications. Here we report a new population of stem cells isolated from the root apical papilla of human teeth (SCAP, stem cells from apical papilla). Using a minipig model, we transplanted both human SCAP and periodontal ligament stem cells (PDLSCs) to generate a root/periodontal complex capable of supporting a porcelain crown, resulting in normal tooth function. This work integrates a stem cell-mediated tissue regeneration strategy, engineered materials for structure, and current dental crown technologies. This hybridized tissue engineering approach led to recovery of tooth strength and appearance.

AB - Mesenchymal stem cell-mediated tissue regeneration is a promising approach for regenerative medicine for a wide range of applications. Here we report a new population of stem cells isolated from the root apical papilla of human teeth (SCAP, stem cells from apical papilla). Using a minipig model, we transplanted both human SCAP and periodontal ligament stem cells (PDLSCs) to generate a root/periodontal complex capable of supporting a porcelain crown, resulting in normal tooth function. This work integrates a stem cell-mediated tissue regeneration strategy, engineered materials for structure, and current dental crown technologies. This hybridized tissue engineering approach led to recovery of tooth strength and appearance.

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Mesenchymal stem cell-mediated functional tooth regeneration in Swine

Abstract

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