Abstract
Introduction: Intrahepatic cholestasis of pregnancy (ICP) is a common maternal liver disease; development can result in devastating consequences, including sudden fetal death and stillbirth. Currently, recognition of ICP only occurs following onset of clinical symptoms. Objective: Investigate the maternal hair metabolome for predictive biomarkers of ICP. Methods: The maternal hair metabolome (gestational age of sampling between 17 and 41 weeks) of 38 Chinese women with ICP and 46 pregnant controls was analysed using gas chromatography–mass spectrometry. Results: Of 105 metabolites detected in hair, none were significantly associated with ICP. Conclusion: Hair samples represent accumulative environmental exposure over time. Samples collected at the onset of ICP did not reveal any metabolic shifts, suggesting rapid development of the disease.
Original language | English |
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Article number | 79 |
Journal | Metabolomics |
Volume | 14 |
Issue number | 6 |
DOIs | |
Publication status | Published or Issued - 1 Jun 2018 |
Externally published | Yes |
Keywords
- Gas chromatography–mass spectrometry
- Hair
- Intrahepatic cholestasis of pregnancy
- Metabolomics
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Biochemistry
- Clinical Biochemistry