MicroRNAs and EMT in mammary cells and breast cancer

Josephine A. Wright; Jennifer K. Richer; Gregory J. Goodall

doi:10.1007/s10911-010-9183-z

MicroRNAs and EMT in mammary cells and breast cancer

Josephine A. Wright, Jennifer K. Richer, Gregory J. Goodall

Research output: Contribution to journal › Review article › peer-review

51 Citations (Scopus)

Abstract

MicroRNAs are master regulators of gene expression in many biological and pathological processes, including mammary gland development and breast cancer. The differentiation program termed the epithelial to mesenchymal transition (EMT) involves changes in a number of microRNAs. Some of these microRNAs have been shown to control cellular plasticity through the suppression of EMT-inducers or to influence cellular phenotype through the suppression of genes involved in defining the epithelial and mesenchymal cell states. This has led to the suggestion that microRNAs maybe a novel therapeutic target for the treatment of breast cancer. In this review, we will discuss microRNAs that are involved in EMT in mammary cells and breast cancer.

Original language	English
Pages (from-to)	213-223
Number of pages	11
Journal	Journal of Mammary Gland Biology and Neoplasia
Volume	15
Issue number	2
DOIs	https://doi.org/10.1007/s10911-010-9183-z
Publication status	Published or Issued - Jun 2010
Externally published	Yes

Keywords

Breast cancer
Epithelial to mesenchymal transition
Mammary cells
MicroRNA

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1007/s10911-010-9183-z

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title = "MicroRNAs and EMT in mammary cells and breast cancer",

abstract = "MicroRNAs are master regulators of gene expression in many biological and pathological processes, including mammary gland development and breast cancer. The differentiation program termed the epithelial to mesenchymal transition (EMT) involves changes in a number of microRNAs. Some of these microRNAs have been shown to control cellular plasticity through the suppression of EMT-inducers or to influence cellular phenotype through the suppression of genes involved in defining the epithelial and mesenchymal cell states. This has led to the suggestion that microRNAs maybe a novel therapeutic target for the treatment of breast cancer. In this review, we will discuss microRNAs that are involved in EMT in mammary cells and breast cancer.",

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AU - Richer, Jennifer K.

AU - Goodall, Gregory J.

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AB - MicroRNAs are master regulators of gene expression in many biological and pathological processes, including mammary gland development and breast cancer. The differentiation program termed the epithelial to mesenchymal transition (EMT) involves changes in a number of microRNAs. Some of these microRNAs have been shown to control cellular plasticity through the suppression of EMT-inducers or to influence cellular phenotype through the suppression of genes involved in defining the epithelial and mesenchymal cell states. This has led to the suggestion that microRNAs maybe a novel therapeutic target for the treatment of breast cancer. In this review, we will discuss microRNAs that are involved in EMT in mammary cells and breast cancer.

KW - Breast cancer

KW - Epithelial to mesenchymal transition

KW - Mammary cells

KW - MicroRNA

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IS - 2

ER -

MicroRNAs and EMT in mammary cells and breast cancer

Abstract

Keywords

ASJC Scopus subject areas

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