TY - JOUR
T1 - Mode of action of the new antibiotic for Gram-positive pathogens daptomycin
T2 - Comparison with cationic antimicrobial peptides and lipopeptides
AU - Straus, Suzana K.
AU - Hancock, Robert E.W.
N1 - Funding Information:
The authors would like to thank the many co-workers who were involved in different aspects of the work on daptomycin: David Jung, Jon-Paul Powers, Mark Okon, Steven W. Ho, Walter R.P. Scott, Annett Rozek, Jennifer Calhoun, James D. Lear, and Jared Silverman. SKS gratefully acknowledges the support of NSERC through a Discovery Grant and a University Faculty Award and UBC. REWH was funded by the Applied Food and Materials Network for this research and by a contract from Cubist Pharmaceuticals, and is the recipient of a Canada Research Chair.
PY - 2006/9
Y1 - 2006/9
N2 - With the steady rise in the number of antibiotic-resistant Gram-positive pathogens, it has become increasingly important to find new antibacterial agents which are highly active and have novel and diversified mechanisms of action. Two classes will be discussed here: the cationic antimicrobial peptides, which are amphiphilic in nature, targeting membranes and increasing their permeability; and lipopeptides, which consist of linear or cyclic peptides with an N-terminus that is acylated with a fatty acid side chain. One member of the cyclic lipopeptide family, the anionic molecule daptomycin, has been extensively studied and is the major focus of this review. Models will be presented on its mode of action and comparisons will be made to the known modes of action of cationic antimicrobial peptides and other lipopeptides.
AB - With the steady rise in the number of antibiotic-resistant Gram-positive pathogens, it has become increasingly important to find new antibacterial agents which are highly active and have novel and diversified mechanisms of action. Two classes will be discussed here: the cationic antimicrobial peptides, which are amphiphilic in nature, targeting membranes and increasing their permeability; and lipopeptides, which consist of linear or cyclic peptides with an N-terminus that is acylated with a fatty acid side chain. One member of the cyclic lipopeptide family, the anionic molecule daptomycin, has been extensively studied and is the major focus of this review. Models will be presented on its mode of action and comparisons will be made to the known modes of action of cationic antimicrobial peptides and other lipopeptides.
KW - Cationic peptide
KW - Daptomycin
KW - Gram-positive pathogen
KW - Lipopeptide
KW - Mechanism of action
UR - https://www.scopus.com/pages/publications/33748946749
U2 - 10.1016/j.bbamem.2006.02.009
DO - 10.1016/j.bbamem.2006.02.009
M3 - Review article
C2 - 16615993
AN - SCOPUS:33748946749
SN - 0005-2736
VL - 1758
SP - 1215
EP - 1223
JO - Biochimica et Biophysica Acta - Biomembranes
JF - Biochimica et Biophysica Acta - Biomembranes
IS - 9
ER -