Monte Carlo simulations of dose distributions with necrotic tumor targeted radioimmunotherapy

Scott N. Penfold; Michael P. Brown; Alexander H. Staudacher; Eva Bezak

doi:10.1016/j.apradiso.2014.03.006

Monte Carlo simulations of dose distributions with necrotic tumor targeted radioimmunotherapy

Scott N. Penfold, Michael P. Brown, Alexander H. Staudacher, Eva Bezak

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Radio-resistant hypoxic tumor cells are significant contributors to the locoregional recurrences and distant metastases that mark failure of radiotherapy. Due to restricted tissue oxygenation, chronically hypoxic tumor cells frequently become necrotic and thus there is often an association between chronically hypoxic and necrotic tumor regions. This simulation study is the first in a series to determine the feasibility of hypoxic cell killing after first targeting adjacent areas of necrosis with either an α- or β-emitting radioimmunoconjugate.

Original language	English
Pages (from-to)	40-45
Number of pages	6
Journal	Applied Radiation and Isotopes
Volume	90
DOIs	https://doi.org/10.1016/j.apradiso.2014.03.006
Publication status	Published or Issued - Aug 2014
Externally published	Yes

Keywords

Hypoxia
La antigen
Monte carlo simulations
Radioimmunotherapy
Targeted alpha therapy

ASJC Scopus subject areas

Radiation

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10.1016/j.apradiso.2014.03.006

Cite this

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title = "Monte Carlo simulations of dose distributions with necrotic tumor targeted radioimmunotherapy",

abstract = "Radio-resistant hypoxic tumor cells are significant contributors to the locoregional recurrences and distant metastases that mark failure of radiotherapy. Due to restricted tissue oxygenation, chronically hypoxic tumor cells frequently become necrotic and thus there is often an association between chronically hypoxic and necrotic tumor regions. This simulation study is the first in a series to determine the feasibility of hypoxic cell killing after first targeting adjacent areas of necrosis with either an α- or β-emitting radioimmunoconjugate.",

keywords = "Hypoxia, La antigen, Monte carlo simulations, Radioimmunotherapy, Targeted alpha therapy",

author = "Penfold, {Scott N.} and Brown, {Michael P.} and Staudacher, {Alexander H.} and Eva Bezak",

year = "2014",

month = aug,

doi = "10.1016/j.apradiso.2014.03.006",

language = "English",

volume = "90",

pages = "40--45",

journal = "Applied Radiation and Isotopes",

issn = "0969-8043",

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T1 - Monte Carlo simulations of dose distributions with necrotic tumor targeted radioimmunotherapy

AU - Penfold, Scott N.

AU - Brown, Michael P.

AU - Staudacher, Alexander H.

AU - Bezak, Eva

PY - 2014/8

Y1 - 2014/8

N2 - Radio-resistant hypoxic tumor cells are significant contributors to the locoregional recurrences and distant metastases that mark failure of radiotherapy. Due to restricted tissue oxygenation, chronically hypoxic tumor cells frequently become necrotic and thus there is often an association between chronically hypoxic and necrotic tumor regions. This simulation study is the first in a series to determine the feasibility of hypoxic cell killing after first targeting adjacent areas of necrosis with either an α- or β-emitting radioimmunoconjugate.

AB - Radio-resistant hypoxic tumor cells are significant contributors to the locoregional recurrences and distant metastases that mark failure of radiotherapy. Due to restricted tissue oxygenation, chronically hypoxic tumor cells frequently become necrotic and thus there is often an association between chronically hypoxic and necrotic tumor regions. This simulation study is the first in a series to determine the feasibility of hypoxic cell killing after first targeting adjacent areas of necrosis with either an α- or β-emitting radioimmunoconjugate.

KW - Hypoxia

KW - La antigen

KW - Monte carlo simulations

KW - Radioimmunotherapy

KW - Targeted alpha therapy

UR - http://www.scopus.com/inward/record.url?scp=84897401932&partnerID=8YFLogxK

U2 - 10.1016/j.apradiso.2014.03.006

DO - 10.1016/j.apradiso.2014.03.006

M3 - Article

C2 - 24685493

AN - SCOPUS:84897401932

SN - 0969-8043

VL - 90

SP - 40

EP - 45

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

ER -

Monte Carlo simulations of dose distributions with necrotic tumor targeted radioimmunotherapy

Abstract

Keywords

ASJC Scopus subject areas

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