mTOR signalling in health and disease

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52 Citations (Scopus)

Abstract

The TOR (target of rapamycin) proteins are found in all eukaryotes. TOR has a protein kinase domain, as well as other domains through which it interacts with partner proteins to form at least two types of multiprotein complex, TORC1 and TORC2 (TOR complexes 1 and 2). Rapamycin, an antibiotic and immunosuppressant, inhibits functions of TORC1. Use of this drug has revealed roles for TORC1 and its mammalian counterpart, mTORC1, in promoting many anabolic processes. mTORC1 signalling is activated by growth factors and nutrients. It is highly active in many cancers and plays a role in tumorigenesis and in other diseases. Much less is known so far about the functions and regulation of (m)TORC2. The goal of this meeting was to bring together researchers studying the roles of mTORC1/2 in normal cell and animal physiology in diverse systems, as well as scientists exploring the therapeutic value of inhibiting mTOR (mammalian TOR) signalling.

Original languageEnglish
Pages (from-to)431-436
Number of pages6
JournalBiochemical Society Transactions
Volume39
Issue number2
DOIs
Publication statusPublished or Issued - Apr 2011
Externally publishedYes

Keywords

  • Mammalian target of rapamycin (mTOR)
  • Protein kinase
  • Rapamycin
  • Signalling
  • Target of rapamycin (TOR)
  • Target of rapamycin complex (TORC)

ASJC Scopus subject areas

  • Biochemistry

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