mTOR's role in ageing: protein synthesis or autophagy?

Sarah L. Hands, Christopher G. Proud, Andreas Wyttenbach

Research output: Contribution to journalReview articlepeer-review

149 Citations (Scopus)


The molecular and cellular mechanisms that regulate ageing are currently under scrutiny because ageing is linked to many human diseases. The nutrient sensing TOR pathway is emerging as a key regulator of ageing. TOR signaling is complex affecting several crucial cellular functions and two such functions, which show clear effects on ageing, are protein synthesis and autophagy. In this article we discuss the relative importance of both these processes in ageing, identify how TOR regulates translation and autophagy and speculate on links between the TOR signaling network and ageing pathways.

Original languageEnglish
Pages (from-to)586-597
Number of pages12
Issue number7
Publication statusPublished or Issued - Jul 2009
Externally publishedYes

ASJC Scopus subject areas

  • Ageing
  • Cell Biology

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