TY - JOUR
T1 - mTOR's role in ageing
T2 - protein synthesis or autophagy?
AU - Hands, Sarah L.
AU - Proud, Christopher G.
AU - Wyttenbach, Andreas
N1 - Copyright:
This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
PY - 2009/7
Y1 - 2009/7
N2 - The molecular and cellular mechanisms that regulate ageing are currently under scrutiny because ageing is linked to many human diseases. The nutrient sensing TOR pathway is emerging as a key regulator of ageing. TOR signaling is complex affecting several crucial cellular functions and two such functions, which show clear effects on ageing, are protein synthesis and autophagy. In this article we discuss the relative importance of both these processes in ageing, identify how TOR regulates translation and autophagy and speculate on links between the TOR signaling network and ageing pathways.
AB - The molecular and cellular mechanisms that regulate ageing are currently under scrutiny because ageing is linked to many human diseases. The nutrient sensing TOR pathway is emerging as a key regulator of ageing. TOR signaling is complex affecting several crucial cellular functions and two such functions, which show clear effects on ageing, are protein synthesis and autophagy. In this article we discuss the relative importance of both these processes in ageing, identify how TOR regulates translation and autophagy and speculate on links between the TOR signaling network and ageing pathways.
UR - http://www.scopus.com/inward/record.url?scp=77953577017&partnerID=8YFLogxK
U2 - 10.18632/aging.100070
DO - 10.18632/aging.100070
M3 - Review article
C2 - 20157541
AN - SCOPUS:77953577017
SN - 1945-4589
VL - 1
SP - 586
EP - 597
JO - Aging
JF - Aging
IS - 7
ER -