Murine Schnurri-2 controls natural killer cell function and lymphoma development

Junji Yamashita, Chiaki Iwamura, Kunitoshi Mitsumori, Hiroyuki Hosokawa, Tetsuya Sasaki, Munehisa Takahashi, Hitoshi Tanaka, Kenji Kaneko, Asami Hanazawa, Yukiko Watanabe, Kenta Shinoda, Damon Tumes, Shinichiro Motohashi, Toshinori Nakayama

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Schnurri (Shn)-2 is a large zinc finger-containing protein implicated in cell growth, signal transduction and lymphocyte development. Here, we report that Shn-2-deficient (Shn-2 -/-) mice develop CD3-positive lymphoma spontaneously. In Shn-2 -/- mice, we observed decreased cytotoxicity of natural killer (NK) cells accompanied by decreased expression of perforin and granzyme-B. In addition, phosphorylation of signal transducer and activator of transcription (STAT) 5 was reduced in Shn-2 -/- NK cells, while phosphorylation of STAT3 and protein expression of nuclear factor-κB p65 subunit were enhanced in Shn-2 -/- NK cells. Moreover, cell-surface expression of activation molecules such as CD27, CD69 and CD122 were decreased on Shn-2 -/- NK cells. Thus, Shn-2 is considered to play an important role in the activation and function of NK cells and the development of T cell lymphoma in vivo.

Original languageEnglish
Pages (from-to)479-486
Number of pages8
JournalLeukemia and Lymphoma
Volume53
Issue number3
DOIs
Publication statusPublished or Issued - Mar 2012

Keywords

  • NK cells
  • Schnnuri2
  • Spontaneous lymphoma

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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