Mutator genes giving rise to decreased antibiotic susceptibility in Pseudomonas aeruginosa

Irith Wiegand; Alexandra K. Marr; Elena B.M. Breidenstein; Kristen N. Schurek; Patrick Taylor; Robert E.W. Hancock

doi:10.1128/AAC.00233-08

Mutator genes giving rise to decreased antibiotic susceptibility in Pseudomonas aeruginosa

Irith Wiegand
, Alexandra K. Marr
, Elena B.M. Breidenstein
, Kristen N. Schurek
, Patrick Taylor
, Robert E.W. Hancock

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Screening of the PA14 genomic transposon mutant library for resistance to ceftazidime, tobramycin, and ciprofloxacin led to the discovery of several mutants that appeared in more than one screen. Testing of the frequency of mutation to ciprofloxacin resistance revealed previously known mutator genes, including mutS and mutL, as well as mutators that have not yet been described for P. aeruginosa, including PA3958 and RadA (PA4609).

Original language	English
Pages (from-to)	3810-3813
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	52
Issue number	10
DOIs	https://doi.org/10.1128/AAC.00233-08
Publication status	Published or Issued - Oct 2008
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.00233-08

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abstract = "Screening of the PA14 genomic transposon mutant library for resistance to ceftazidime, tobramycin, and ciprofloxacin led to the discovery of several mutants that appeared in more than one screen. Testing of the frequency of mutation to ciprofloxacin resistance revealed previously known mutator genes, including mutS and mutL, as well as mutators that have not yet been described for P. aeruginosa, including PA3958 and RadA (PA4609).",

author = "Irith Wiegand and Marr, \{Alexandra K.\} and Breidenstein, \{Elena B.M.\} and Schurek, \{Kristen N.\} and Patrick Taylor and Hancock, \{Robert E.W.\}",

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AU - Marr, Alexandra K.

AU - Breidenstein, Elena B.M.

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AU - Taylor, Patrick

AU - Hancock, Robert E.W.

PY - 2008/10

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AB - Screening of the PA14 genomic transposon mutant library for resistance to ceftazidime, tobramycin, and ciprofloxacin led to the discovery of several mutants that appeared in more than one screen. Testing of the frequency of mutation to ciprofloxacin resistance revealed previously known mutator genes, including mutS and mutL, as well as mutators that have not yet been described for P. aeruginosa, including PA3958 and RadA (PA4609).

UR - https://www.scopus.com/pages/publications/54049152810

U2 - 10.1128/AAC.00233-08

DO - 10.1128/AAC.00233-08

M3 - Article

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AN - SCOPUS:54049152810

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JO - Antimicrobial Agents and Chemotherapy

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ER -

Mutator genes giving rise to decreased antibiotic susceptibility in Pseudomonas aeruginosa

Abstract

ASJC Scopus subject areas

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