Neolithic mitochondrial haplogroup H genomes and the genetic origins of Europeans

Paul Brotherton; Wolfgang Haak; Jennifer Templeton; Guido Brandt; Julien Soubrier; Christina Jane Adler; Stephen M. Richards; Clio Der Sarkissian; Robert Ganslmeier; Susanne Friederich; Veit Dresely; Mannis Van Oven; Rosalie Kenyon; Mark B. Van Der Hoek; Jonas Korlach; Khai Luong; Simon Y.W. Ho; Lluis Quintana-Murci; Doron M. Behar; Harald Meller; Kurt W. Alt; Alan Cooper; Syama Adhikarla; Arun Kumar Ganesh Prasad; Ramasamy Pitchappan; Arun Varatharajan Santhakumari; Elena Balanovska; Oleg Balanovsky; Jaume Bertranpetit; David Comas; Begoña Martínez-Cruz; Marta Melé; Andrew C. Clarke; Elizabeth A. Matisoo-Smith; Matthew C. Dulik; Jill B. Gaieski; Amanda C. Owings; Theodore G. Schurr; Miguel G. Vilar; Angela Hobbs; Himla Soodyall; Asif Javed; Laxmi Parida; Daniel E. Platt; Ajay K. Royyuru; Li Jin; Shilin Li; Matthew E. Kaplan; Nirav C. Merchant; R. John Mitchell; Colin Renfrew; Daniela R. Lacerda; Fabrício R. Santos; David F. Soria Hernanz; R. Spencer Wells; Pandikumar Swamikrishnan; Chris Tyler-Smith; Pedro Paulo Vieira; Janet S. Ziegle

doi:10.1038/ncomms2656

Neolithic mitochondrial haplogroup H genomes and the genetic origins of Europeans

Paul Brotherton, Wolfgang Haak, Jennifer Templeton, Guido Brandt, Julien Soubrier, Christina Jane Adler, Stephen M. Richards, Clio Der Sarkissian, Robert Ganslmeier, Susanne Friederich, Veit Dresely, Mannis Van Oven, Rosalie Kenyon, Mark B. Van Der Hoek, Jonas Korlach, Khai Luong, Simon Y.W. Ho, Lluis Quintana-Murci, Doron M. Behar, Harald MellerKurt W. Alt, Alan Cooper, Syama Adhikarla, Arun Kumar Ganesh Prasad, Ramasamy Pitchappan, Arun Varatharajan Santhakumari, Elena Balanovska, Oleg Balanovsky, Jaume Bertranpetit, David Comas, Begoña Martínez-Cruz, Marta Melé, Andrew C. Clarke, Elizabeth A. Matisoo-Smith, Matthew C. Dulik, Jill B. Gaieski, Amanda C. Owings, Theodore G. Schurr, Miguel G. Vilar, Angela Hobbs, Himla Soodyall, Asif Javed, Laxmi Parida, Daniel E. Platt, Ajay K. Royyuru, Li Jin, Shilin Li, Matthew E. Kaplan, Nirav C. Merchant, R. John Mitchell, Colin Renfrew, Daniela R. Lacerda, Fabrício R. Santos, David F. Soria Hernanz, R. Spencer Wells, Pandikumar Swamikrishnan, Chris Tyler-Smith, Pedro Paulo Vieira, Janet S. Ziegle

Research output: Contribution to journal › Article › peer-review

170 Citations (Scopus)

Abstract

Haplogroup H dominates present-day Western European mitochondrial DNA variability (>40%), yet was less common (∼19%) among Early Neolithic farmers (∼5450 BC) and virtually absent in Mesolithic hunter-gatherers. Here we investigate this major component of the maternal population history of modern Europeans and sequence 39 complete haplogroup H mitochondrial genomes from ancient human remains. We then compare this 'real-time' genetic data with cultural changes taking place between the Early Neolithic (∼5450 BC) and Bronze Age (∼2200 BC) in Central Europe. Our results reveal that the current diversity and distribution of haplogroup H were largely established by the Mid Neolithic (∼4000 BC), but with substantial genetic contributions from subsequent pan-European cultures such as the Bell Beakers expanding out of Iberia in the Late Neolithic (∼2800 BC). Dated haplogroup H genomes allow us to reconstruct the recent evolutionary history of haplogroup H and reveal a mutation rate 45% higher than current estimates for human mitochondria.

Original language	English
Article number	1764
Journal	Nature Communications
Volume	4
DOIs	https://doi.org/10.1038/ncomms2656
Publication status	Published or Issued - 2013
Externally published	Yes

ASJC Scopus subject areas

Chemistry(all)
Biochemistry, Genetics and Molecular Biology(all)
Physics and Astronomy(all)

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Brotherton, P., Haak, W., Templeton, J., Brandt, G., Soubrier, J., Jane Adler, C., Richards, S. M., Sarkissian, C. D., Ganslmeier, R., Friederich, S., Dresely, V., Van Oven, M., Kenyon, R., Van Der Hoek, M. B., Korlach, J., Luong, K., Ho, S. Y. W., Quintana-Murci, L., Behar, D. M., ... Ziegle, J. S. (2013). Neolithic mitochondrial haplogroup H genomes and the genetic origins of Europeans. Nature Communications, 4, Article 1764. https://doi.org/10.1038/ncomms2656

@article{a340c725a0da410d9ecd0b42350eb020,

title = "Neolithic mitochondrial haplogroup H genomes and the genetic origins of Europeans",

abstract = "Haplogroup H dominates present-day Western European mitochondrial DNA variability (>40%), yet was less common (∼19%) among Early Neolithic farmers (∼5450 BC) and virtually absent in Mesolithic hunter-gatherers. Here we investigate this major component of the maternal population history of modern Europeans and sequence 39 complete haplogroup H mitochondrial genomes from ancient human remains. We then compare this 'real-time' genetic data with cultural changes taking place between the Early Neolithic (∼5450 BC) and Bronze Age (∼2200 BC) in Central Europe. Our results reveal that the current diversity and distribution of haplogroup H were largely established by the Mid Neolithic (∼4000 BC), but with substantial genetic contributions from subsequent pan-European cultures such as the Bell Beakers expanding out of Iberia in the Late Neolithic (∼2800 BC). Dated haplogroup H genomes allow us to reconstruct the recent evolutionary history of haplogroup H and reveal a mutation rate 45% higher than current estimates for human mitochondria.",

author = "Paul Brotherton and Wolfgang Haak and Jennifer Templeton and Guido Brandt and Julien Soubrier and {Jane Adler}, Christina and Richards, {Stephen M.} and Sarkissian, {Clio Der} and Robert Ganslmeier and Susanne Friederich and Veit Dresely and {Van Oven}, Mannis and Rosalie Kenyon and {Van Der Hoek}, {Mark B.} and Jonas Korlach and Khai Luong and Ho, {Simon Y.W.} and Lluis Quintana-Murci and Behar, {Doron M.} and Harald Meller and Alt, {Kurt W.} and Alan Cooper and Syama Adhikarla and {Ganesh Prasad}, {Arun Kumar} and Ramasamy Pitchappan and {Varatharajan Santhakumari}, Arun and Elena Balanovska and Oleg Balanovsky and Jaume Bertranpetit and David Comas and Bego{\~n}a Mart{\'i}nez-Cruz and Marta Mel{\'e} and Clarke, {Andrew C.} and Matisoo-Smith, {Elizabeth A.} and Dulik, {Matthew C.} and Gaieski, {Jill B.} and Owings, {Amanda C.} and Schurr, {Theodore G.} and Vilar, {Miguel G.} and Angela Hobbs and Himla Soodyall and Asif Javed and Laxmi Parida and Platt, {Daniel E.} and Royyuru, {Ajay K.} and Li Jin and Shilin Li and Kaplan, {Matthew E.} and Merchant, {Nirav C.} and {John Mitchell}, R. and Colin Renfrew and Lacerda, {Daniela R.} and Santos, {Fabr{\'i}cio R.} and {Soria Hernanz}, {David F.} and {Spencer Wells}, R. and Pandikumar Swamikrishnan and Chris Tyler-Smith and {Paulo Vieira}, Pedro and Ziegle, {Janet S.}",

year = "2013",

doi = "10.1038/ncomms2656",

language = "English",

volume = "4",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Publishing Group",

}

Brotherton, P, Haak, W, Templeton, J, Brandt, G, Soubrier, J, Jane Adler, C, Richards, SM, Sarkissian, CD, Ganslmeier, R, Friederich, S, Dresely, V, Van Oven, M, Kenyon, R, Van Der Hoek, MB, Korlach, J, Luong, K, Ho, SYW, Quintana-Murci, L, Behar, DM, Meller, H, Alt, KW, Cooper, A, Adhikarla, S, Ganesh Prasad, AK, Pitchappan, R, Varatharajan Santhakumari, A, Balanovska, E, Balanovsky, O, Bertranpetit, J, Comas, D, Martínez-Cruz, B, Melé, M, Clarke, AC, Matisoo-Smith, EA, Dulik, MC, Gaieski, JB, Owings, AC, Schurr, TG, Vilar, MG, Hobbs, A, Soodyall, H, Javed, A, Parida, L, Platt, DE, Royyuru, AK, Jin, L, Li, S, Kaplan, ME, Merchant, NC, John Mitchell, R, Renfrew, C, Lacerda, DR, Santos, FR, Soria Hernanz, DF, Spencer Wells, R, Swamikrishnan, P, Tyler-Smith, C, Paulo Vieira, P & Ziegle, JS 2013, 'Neolithic mitochondrial haplogroup H genomes and the genetic origins of Europeans', Nature Communications, vol. 4, 1764. https://doi.org/10.1038/ncomms2656

TY - JOUR

T1 - Neolithic mitochondrial haplogroup H genomes and the genetic origins of Europeans

AU - Brotherton, Paul

AU - Haak, Wolfgang

AU - Templeton, Jennifer

AU - Brandt, Guido

AU - Soubrier, Julien

AU - Jane Adler, Christina

AU - Richards, Stephen M.

AU - Sarkissian, Clio Der

AU - Ganslmeier, Robert

AU - Friederich, Susanne

AU - Dresely, Veit

AU - Van Oven, Mannis

AU - Kenyon, Rosalie

AU - Van Der Hoek, Mark B.

AU - Korlach, Jonas

AU - Luong, Khai

AU - Ho, Simon Y.W.

AU - Quintana-Murci, Lluis

AU - Behar, Doron M.

AU - Meller, Harald

AU - Alt, Kurt W.

AU - Cooper, Alan

AU - Adhikarla, Syama

AU - Ganesh Prasad, Arun Kumar

AU - Pitchappan, Ramasamy

AU - Varatharajan Santhakumari, Arun

AU - Balanovska, Elena

AU - Balanovsky, Oleg

AU - Bertranpetit, Jaume

AU - Comas, David

AU - Martínez-Cruz, Begoña

AU - Melé, Marta

AU - Clarke, Andrew C.

AU - Matisoo-Smith, Elizabeth A.

AU - Dulik, Matthew C.

AU - Gaieski, Jill B.

AU - Owings, Amanda C.

AU - Schurr, Theodore G.

AU - Vilar, Miguel G.

AU - Hobbs, Angela

AU - Soodyall, Himla

AU - Javed, Asif

AU - Parida, Laxmi

AU - Platt, Daniel E.

AU - Royyuru, Ajay K.

AU - Jin, Li

AU - Li, Shilin

AU - Kaplan, Matthew E.

AU - Merchant, Nirav C.

AU - John Mitchell, R.

AU - Renfrew, Colin

AU - Lacerda, Daniela R.

AU - Santos, Fabrício R.

AU - Soria Hernanz, David F.

AU - Spencer Wells, R.

AU - Swamikrishnan, Pandikumar

AU - Tyler-Smith, Chris

AU - Paulo Vieira, Pedro

AU - Ziegle, Janet S.

PY - 2013

Y1 - 2013

N2 - Haplogroup H dominates present-day Western European mitochondrial DNA variability (>40%), yet was less common (∼19%) among Early Neolithic farmers (∼5450 BC) and virtually absent in Mesolithic hunter-gatherers. Here we investigate this major component of the maternal population history of modern Europeans and sequence 39 complete haplogroup H mitochondrial genomes from ancient human remains. We then compare this 'real-time' genetic data with cultural changes taking place between the Early Neolithic (∼5450 BC) and Bronze Age (∼2200 BC) in Central Europe. Our results reveal that the current diversity and distribution of haplogroup H were largely established by the Mid Neolithic (∼4000 BC), but with substantial genetic contributions from subsequent pan-European cultures such as the Bell Beakers expanding out of Iberia in the Late Neolithic (∼2800 BC). Dated haplogroup H genomes allow us to reconstruct the recent evolutionary history of haplogroup H and reveal a mutation rate 45% higher than current estimates for human mitochondria.

AB - Haplogroup H dominates present-day Western European mitochondrial DNA variability (>40%), yet was less common (∼19%) among Early Neolithic farmers (∼5450 BC) and virtually absent in Mesolithic hunter-gatherers. Here we investigate this major component of the maternal population history of modern Europeans and sequence 39 complete haplogroup H mitochondrial genomes from ancient human remains. We then compare this 'real-time' genetic data with cultural changes taking place between the Early Neolithic (∼5450 BC) and Bronze Age (∼2200 BC) in Central Europe. Our results reveal that the current diversity and distribution of haplogroup H were largely established by the Mid Neolithic (∼4000 BC), but with substantial genetic contributions from subsequent pan-European cultures such as the Bell Beakers expanding out of Iberia in the Late Neolithic (∼2800 BC). Dated haplogroup H genomes allow us to reconstruct the recent evolutionary history of haplogroup H and reveal a mutation rate 45% higher than current estimates for human mitochondria.

UR - http://www.scopus.com/inward/record.url?scp=84877780848&partnerID=8YFLogxK

U2 - 10.1038/ncomms2656

DO - 10.1038/ncomms2656

M3 - Article

C2 - 23612305

AN - SCOPUS:84877780848

SN - 2041-1723

VL - 4

JO - Nature Communications

JF - Nature Communications

M1 - 1764

ER -

Neolithic mitochondrial haplogroup H genomes and the genetic origins of Europeans

Abstract

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