Neuro-Mesenchymal Interaction Mediated by a β2-Adrenergic Nerve Growth Factor Feedforward Loop Promotes Colorectal Cancer Progression

Hiroki Kobayashi, Tadashi Iida, Yosuke Ochiai, Ermanno Malagola, Xiaofei Zhi, Ruth A. White, Jin Qian, Feijing Wu, Quin T. Waterbury, Ruhong Tu, Biyun Zheng, Jonathan S. LaBella, Leah B. Zamechek, Atsushi Ogura, Susan L. Woods, Daniel L. Worthley, Atsushi Enomoto, Timothy C. Wang

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

SIGNIFICANCE: Our work demonstrates that the bidirectional interplay between sympathetic nerves and NGF-expressing CAFs drives colorectal tumorigenesis. This study also offers novel mechanistic insights into catecholamine action in colorectal cancer. Inhibiting the neuro-mesenchymal interaction by TRK blockade could be a potential strategy for treating colorectal cancer.

Original languageEnglish
Pages (from-to)202-226
Number of pages25
JournalCancer Discovery
Volume15
Issue number1
DOIs
Publication statusPublished or Issued - 13 Jan 2025

ASJC Scopus subject areas

  • Oncology

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