@article{257b2acc000e4b61bfac2af8c5da22b6,
title = "Neuro-Mesenchymal Interaction Mediated by a β2-Adrenergic Nerve Growth Factor Feedforward Loop Promotes Colorectal Cancer Progression",
abstract = "SIGNIFICANCE: Our work demonstrates that the bidirectional interplay between sympathetic nerves and NGF-expressing CAFs drives colorectal tumorigenesis. This study also offers novel mechanistic insights into catecholamine action in colorectal cancer. Inhibiting the neuro-mesenchymal interaction by TRK blockade could be a potential strategy for treating colorectal cancer.",
author = "Hiroki Kobayashi and Tadashi Iida and Yosuke Ochiai and Ermanno Malagola and Xiaofei Zhi and White, {Ruth A.} and Jin Qian and Feijing Wu and Waterbury, {Quin T.} and Ruhong Tu and Biyun Zheng and LaBella, {Jonathan S.} and Zamechek, {Leah B.} and Atsushi Ogura and Woods, {Susan L.} and Worthley, {Daniel L.} and Atsushi Enomoto and Wang, {Timothy C.}",
note = "Publisher Copyright: {\textcopyright}2024 American Association for Cancer Research.",
year = "2025",
month = jan,
day = "13",
doi = "10.1158/2159-8290.CD-24-0287",
language = "English",
volume = "15",
pages = "202--226",
journal = "Cancer Discovery",
issn = "2159-8274",
publisher = "American Association for Cancer Research Inc.",
number = "1",
}