Neuropilin-2 genomic elements drive cre recombinase expression in primitive blood, vascular and neuronal lineages

Sophie Wiszniak, Michaela Scherer, Hayley Ramshaw, Quenten Schwarz

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


We have established a novel Cre mouse line, using genomic elements encompassing the Nrp2 locus, present within a bacterial artificial chromosome clone. By crossing this Cre driver line to R26R LacZ reporter mice, we have documented the temporal expression and lineage traced tissues in which Cre is expressed. Nrp2-Cre drives expression in primitive blood cells arising from the yolk sac, venous and lymphatic endothelial cells, peripheral sensory ganglia, and the lung bud. This mouse line will provide a new tool to researchers wishing to study the development of various tissues and organs in which this Cre driver is expressed, as well as allow tissue-specific knockout of genes of interest to study protein function. This work also presents the first evidence for expression of Nrp2 protein in a mesodermal progenitor with restricted hematopoietic potential, which will significantly advance the study of primitive erythropoiesis.

Original languageEnglish
Pages (from-to)709-717
Number of pages9
Issue number11
Publication statusPublished or Issued - 1 Nov 2015
Externally publishedYes


  • Cre
  • Enhancer
  • Erythrocyte
  • Neural crest
  • Neuropilin
  • Nrp2
  • Vascular

ASJC Scopus subject areas

  • Genetics
  • Endocrinology
  • Cell Biology

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