Abstract
Neutrophil-activating peptide-1/interleukin-8 (NAP-1/IL-8) is a cytokine synthesized by various cell types. In the immune system NAP-1/IL-8 is part of an immune cascade initiated by IL-1 production. NAP-1/ IL-8 affects hypothalamic function and its production is suppressed by steroids. Therefore, it might be expected that NAP-l/IL-8 would be produced in brain areas involved in the control of the hypothalamic-pituitary-adrenocortical axis (HPA). NAP-1/IL-8 mRNA was localized by in situ hybridization in the paraventricular nucleus of the hypothalamus and hippocampus. Those areas also express the genes encoding interleukin-1-alpha (IL-lα), IL-lβ, IL-1 receptors, and IL-1 receptor antagonist (IL-lra). This suggests that an immune cascade, which is well characterized in the immune system, may exist in brain, in areas of relevance to the regulation of stress-related neuroendocrine function.
| Original language | English |
|---|---|
| Pages (from-to) | 753-756 |
| Number of pages | 4 |
| Journal | NeuroReport |
| Volume | 3 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published or Issued - 1 Jan 1992 |
Keywords
- Hippocampus
- Interleukin-8
- Messenger RNA
- Nucleic acid hybridization
- Paraventricular hypothalamic nucleus
- Rat
ASJC Scopus subject areas
- Neuroscience(all)