Neutrophil-activating peptide-1 /interleukin-8 mRNA is localized in rat hypothalamus and hippocampus

Julio Licinio, Ma Li Wong, Philip W. Gold

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26 Citations (Scopus)

Abstract

Neutrophil-activating peptide-1/interleukin-8 (NAP-1/IL-8) is a cytokine synthesized by various cell types. In the immune system NAP-1/IL-8 is part of an immune cascade initiated by IL-1 production. NAP-1/ IL-8 affects hypothalamic function and its production is suppressed by steroids. Therefore, it might be expected that NAP-l/IL-8 would be produced in brain areas involved in the control of the hypothalamic-pituitary-adrenocortical axis (HPA). NAP-1/IL-8 mRNA was localized by in situ hybridization in the paraventricular nucleus of the hypothalamus and hippocampus. Those areas also express the genes encoding interleukin-1-alpha (IL-lα), IL-lβ, IL-1 receptors, and IL-1 receptor antagonist (IL-lra). This suggests that an immune cascade, which is well characterized in the immune system, may exist in brain, in areas of relevance to the regulation of stress-related neuroendocrine function.

Original languageEnglish
Pages (from-to)753-756
Number of pages4
JournalNeuroReport
Volume3
Issue number9
DOIs
Publication statusPublished or Issued - 1 Jan 1992

Keywords

  • Hippocampus
  • Interleukin-8
  • Messenger RNA
  • Nucleic acid hybridization
  • Paraventricular hypothalamic nucleus
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)

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