New drugs for HDL-C disorders: The beginning

My Ngan Duong; Stephen J. Nicholls

doi:10.2174/0929867321666140414104130

New drugs for HDL-C disorders: The beginning

My Ngan Duong, Stephen J. Nicholls

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

For more than 20 years there has been increasing interest in the development of novel therapies to raise levels of high-density lipoprotein cholesterol (HDL-C). However, well publicized failures of recent clinical trials of agents that raise HDL-C levels have stimulated considerable controversy with regard to the potential clinical utility of this therapeutic target. A number of classes of agents are currently under investigation with variable effects on HDL quantity and quality. These will be reviewed.

Original language	English
Pages (from-to)	2947-2951
Number of pages	5
Journal	Current Medicinal Chemistry
Volume	21
Issue number	25
DOIs	https://doi.org/10.2174/0929867321666140414104130
Publication status	Published or Issued - Aug 2014

Keywords

Atherosclerosis
Cardiovascular disease
HDL
Lipids
Risk factors

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Pharmacology
Drug Discovery
Organic Chemistry

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10.2174/0929867321666140414104130

Cite this

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title = "New drugs for HDL-C disorders: The beginning",

abstract = "For more than 20 years there has been increasing interest in the development of novel therapies to raise levels of high-density lipoprotein cholesterol (HDL-C). However, well publicized failures of recent clinical trials of agents that raise HDL-C levels have stimulated considerable controversy with regard to the potential clinical utility of this therapeutic target. A number of classes of agents are currently under investigation with variable effects on HDL quantity and quality. These will be reviewed.",

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AB - For more than 20 years there has been increasing interest in the development of novel therapies to raise levels of high-density lipoprotein cholesterol (HDL-C). However, well publicized failures of recent clinical trials of agents that raise HDL-C levels have stimulated considerable controversy with regard to the potential clinical utility of this therapeutic target. A number of classes of agents are currently under investigation with variable effects on HDL quantity and quality. These will be reviewed.

KW - Atherosclerosis

KW - Cardiovascular disease

KW - HDL

KW - Lipids

KW - Risk factors

UR - https://www.scopus.com/pages/publications/84906095401

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DO - 10.2174/0929867321666140414104130

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ER -

New drugs for HDL-C disorders: The beginning

Abstract

Keywords

ASJC Scopus subject areas

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