Novel cardiovascular magnetic resonance oxygenation approaches in understanding pathophysiology of cardiac diseases

Karthigesh Sree Raman, Gaetano Nucifora, Joseph B. Selvanayagam

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Cardiovascular magnetic resonance imaging (CMR) permits accurate phenotyping of many cardiac diseases. CMR’s inherent advantages are its non-invasive nature, lack of ionizing radiation and high accuracy and reproducibility. Furthermore, it is able to assess many aspects of cardiac anatomy, structure and function. Specifically, it can characterize myocardial tissue, myocardial function, myocardial mass, myocardial blood flow/perfusion, irreversible and reversible injury, all with a high degree of accuracy and reproducibility. Hence, CMR is a powerful tool in clinical and pre-clinical research. In recent years there have been novel advances in CMR myocardial tissue characterization. Oxygenation-sensitive CMR (OS-CMR) is a novel non-invasive, contrast independent technique that permits direct quantification of myocardial tissue oxygenation, both at rest and during stress. In this review, we will address the principles of the OS-CMR technique, its recent advances and summarize the studies in the effects of oxygenation on cardiac diseases.

Original languageEnglish
Pages (from-to)475-480
Number of pages6
JournalClinical and Experimental Pharmacology and Physiology
Issue number5
Publication statusPublished or Issued - May 2018


  • blood oxygen level dependent
  • cardiac magnetic resonance
  • microcirculation
  • oxygen-sensitive cardiovascular magnetic resonance
  • oxygenation

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

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