Nutritional omega-3 modulates neuronal morphology in the prefrontal cortex along with depression-related behavior through corticosterone secretion

T. Larrieu, L. M. Hilal, C. Fourrier, V. De Smedt-Peyrusse, N. Sans, L. Capuron, S. Layé

Research output: Contribution to journalArticlepeer-review

106 Citations (Scopus)

Abstract

Understanding how malnutrition contributes to depression is building momentum. In the present study we unravel molecular and cellular mechanisms by which nutritional disturbances lead to impaired emotional behaviour in mice. Here we report that nutritional n-3 polyunsaturated fatty acids (PUFA) deficiency induces a chronic stress state reflected by disrupted glucocorticoid receptor (GR)-mediated signalling pathway along with hypothalamic-pituitary-adrenal (HPA) axis hyperactivity. This hyperactivity in turn resulted in neuronal atrophy in the dorsolateral (dl)- and dorsomedial (dm)- prefrontal cortex (PFC) and subsequent moodrelated behaviour alterations, similarly to chronic social defeat stress. Supplementation of n-3 PUFA prevented detrimental chronic social defeat stress-induced emotional and neuronal impairments by impeding HPA axis hyperactivity. These results indicate a role for dietary n-3 PUFA in the prevention of HPA axis dysfunction associated with the development of some neuropsychiatric disorders including depression.

Original languageEnglish
Article numbere437
JournalTranslational psychiatry
Volume4
Issue number9
DOIs
Publication statusPublished or Issued - 1 Jan 2014
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Biological Psychiatry

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