Organochlorine levels in plasma and risk of multiple myeloma

Leah Weber; Kevin Song; Terry Boyle; Éric Gaudreau; Agnes Lai; Heather J. Sutherland; Alain LeBlanc; John J. Spinelli

doi:10.1097/JOM.0000000000001387

Organochlorine levels in plasma and risk of multiple myeloma

Leah Weber, Kevin Song, Terry Boyle, Éric Gaudreau, Agnes Lai, Heather J. Sutherland, Alain LeBlanc, John J. Spinelli

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Objective: The aim of this study was to estimate the association between organochlorine pesticides and polychlorinated biphenyls (PCBs) and multiple myeloma (MM). Methods: The risk of MM from organochlorine compounds was examined in a population-based case-control study in British Columbia, Canada. Congeners of PCBs and pesticides or pesticide metabolites were measured in plasma of 325 cases and 327 controls. Results: Most organochlorine analytes showed a significant association with MM. The strongest association (highest vs lowest quartile) was oxychlordane (odds ratio=7.44; 95% confidence interval=4.19 to 13.21). No heterogeneity was detected between organochlorines levels and MM subtypes. Only oxychlordane and b-hexachlorocyclohexane (b-HCCH) were identified as significant independent predictors of MM. Conclusion: Our study provides evidence that organochlorines contribute to the risk of MM.

Original language	English
Pages (from-to)	911-916
Number of pages	6
Journal	Journal of Occupational and Environmental Medicine
Volume	60
Issue number	10
DOIs	https://doi.org/10.1097/JOM.0000000000001387
Publication status	Published or Issued - 2018
Externally published	Yes

Keywords

Case-control study
Epidemiology
Multiple myeloma
Organochlorines
Polychlorinated biphenyls

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health

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10.1097/JOM.0000000000001387

Cite this

@article{113fdb907e07452d8ec11b105e2ef52d,

title = "Organochlorine levels in plasma and risk of multiple myeloma",

abstract = "Objective: The aim of this study was to estimate the association between organochlorine pesticides and polychlorinated biphenyls (PCBs) and multiple myeloma (MM). Methods: The risk of MM from organochlorine compounds was examined in a population-based case-control study in British Columbia, Canada. Congeners of PCBs and pesticides or pesticide metabolites were measured in plasma of 325 cases and 327 controls. Results: Most organochlorine analytes showed a significant association with MM. The strongest association (highest vs lowest quartile) was oxychlordane (odds ratio=7.44; 95% confidence interval=4.19 to 13.21). No heterogeneity was detected between organochlorines levels and MM subtypes. Only oxychlordane and b-hexachlorocyclohexane (b-HCCH) were identified as significant independent predictors of MM. Conclusion: Our study provides evidence that organochlorines contribute to the risk of MM.",

keywords = "Case-control study, Epidemiology, Multiple myeloma, Organochlorines, Polychlorinated biphenyls",

author = "Leah Weber and Kevin Song and Terry Boyle and {\'E}ric Gaudreau and Agnes Lai and Sutherland, {Heather J.} and Alain LeBlanc and Spinelli, {John J.}",

note = "Publisher Copyright: {\textcopyright} 2018 American College of Occupational and Environmental Medicine.",

year = "2018",

doi = "10.1097/JOM.0000000000001387",

language = "English",

volume = "60",

pages = "911--916",

journal = "Journal of Occupational and Environmental Medicine",

issn = "1076-2752",

publisher = "Lippincott Williams and Wilkins Ltd.",

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}

TY - JOUR

T1 - Organochlorine levels in plasma and risk of multiple myeloma

AU - Weber, Leah

AU - Song, Kevin

AU - Boyle, Terry

AU - Gaudreau, Éric

AU - Lai, Agnes

AU - Sutherland, Heather J.

AU - LeBlanc, Alain

AU - Spinelli, John J.

PY - 2018

Y1 - 2018

N2 - Objective: The aim of this study was to estimate the association between organochlorine pesticides and polychlorinated biphenyls (PCBs) and multiple myeloma (MM). Methods: The risk of MM from organochlorine compounds was examined in a population-based case-control study in British Columbia, Canada. Congeners of PCBs and pesticides or pesticide metabolites were measured in plasma of 325 cases and 327 controls. Results: Most organochlorine analytes showed a significant association with MM. The strongest association (highest vs lowest quartile) was oxychlordane (odds ratio=7.44; 95% confidence interval=4.19 to 13.21). No heterogeneity was detected between organochlorines levels and MM subtypes. Only oxychlordane and b-hexachlorocyclohexane (b-HCCH) were identified as significant independent predictors of MM. Conclusion: Our study provides evidence that organochlorines contribute to the risk of MM.

AB - Objective: The aim of this study was to estimate the association between organochlorine pesticides and polychlorinated biphenyls (PCBs) and multiple myeloma (MM). Methods: The risk of MM from organochlorine compounds was examined in a population-based case-control study in British Columbia, Canada. Congeners of PCBs and pesticides or pesticide metabolites were measured in plasma of 325 cases and 327 controls. Results: Most organochlorine analytes showed a significant association with MM. The strongest association (highest vs lowest quartile) was oxychlordane (odds ratio=7.44; 95% confidence interval=4.19 to 13.21). No heterogeneity was detected between organochlorines levels and MM subtypes. Only oxychlordane and b-hexachlorocyclohexane (b-HCCH) were identified as significant independent predictors of MM. Conclusion: Our study provides evidence that organochlorines contribute to the risk of MM.

KW - Case-control study

KW - Epidemiology

KW - Multiple myeloma

KW - Organochlorines

KW - Polychlorinated biphenyls

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U2 - 10.1097/JOM.0000000000001387

DO - 10.1097/JOM.0000000000001387

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C2 - 30289833

AN - SCOPUS:85054427986

SN - 1076-2752

VL - 60

SP - 911

EP - 916

JO - Journal of Occupational and Environmental Medicine

JF - Journal of Occupational and Environmental Medicine

IS - 10

ER -

Organochlorine levels in plasma and risk of multiple myeloma

Abstract

Keywords

ASJC Scopus subject areas

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