Organochlorine levels in plasma and risk of multiple myeloma

Leah Weber, Kevin Song, Terry Boyle, Éric Gaudreau, Agnes Lai, Heather J. Sutherland, Alain LeBlanc, John J. Spinelli

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Objective: The aim of this study was to estimate the association between organochlorine pesticides and polychlorinated biphenyls (PCBs) and multiple myeloma (MM). Methods: The risk of MM from organochlorine compounds was examined in a population-based case-control study in British Columbia, Canada. Congeners of PCBs and pesticides or pesticide metabolites were measured in plasma of 325 cases and 327 controls. Results: Most organochlorine analytes showed a significant association with MM. The strongest association (highest vs lowest quartile) was oxychlordane (odds ratio=7.44; 95% confidence interval=4.19 to 13.21). No heterogeneity was detected between organochlorines levels and MM subtypes. Only oxychlordane and b-hexachlorocyclohexane (b-HCCH) were identified as significant independent predictors of MM. Conclusion: Our study provides evidence that organochlorines contribute to the risk of MM.

Original languageEnglish
Pages (from-to)911-916
Number of pages6
JournalJournal of Occupational and Environmental Medicine
Issue number10
Publication statusPublished or Issued - 2018
Externally publishedYes


  • Case-control study
  • Epidemiology
  • Multiple myeloma
  • Organochlorines
  • Polychlorinated biphenyls

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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