Abstract
Objective: The aim of this study was to estimate the association between organochlorine pesticides and polychlorinated biphenyls (PCBs) and multiple myeloma (MM). Methods: The risk of MM from organochlorine compounds was examined in a population-based case-control study in British Columbia, Canada. Congeners of PCBs and pesticides or pesticide metabolites were measured in plasma of 325 cases and 327 controls. Results: Most organochlorine analytes showed a significant association with MM. The strongest association (highest vs lowest quartile) was oxychlordane (odds ratio=7.44; 95% confidence interval=4.19 to 13.21). No heterogeneity was detected between organochlorines levels and MM subtypes. Only oxychlordane and b-hexachlorocyclohexane (b-HCCH) were identified as significant independent predictors of MM. Conclusion: Our study provides evidence that organochlorines contribute to the risk of MM.
| Original language | English |
|---|---|
| Pages (from-to) | 911-916 |
| Number of pages | 6 |
| Journal | Journal of Occupational and Environmental Medicine |
| Volume | 60 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published or Issued - 2018 |
| Externally published | Yes |
Keywords
- Case-control study
- Epidemiology
- Multiple myeloma
- Organochlorines
- Polychlorinated biphenyls
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
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