Abstract
Three novel palladium complexes utilizing different variations of the evolutionary meta-terarylphosphine ligand, Cy∗Phine, were developed. These air- and moisture-stable complexes, PdCl2L2 (L = Cy∗Phine, Cy∗Phine-CF3 and Cy∗Phine-nBu), demonstrated exceptional broad-based performance and operational simplicity in the copper-free Sonogashira cross-coupling of challenging (hetero-)aryl chlorides and terminal alkynes. Modifications to the periphery of the ligand scaffold showed modest improvements in the reaction rate when more electron-donating substituents were incorporated, which hints at potential design upgrades in the future.
Original language | English |
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Pages (from-to) | 3501-3506 |
Number of pages | 6 |
Journal | Catalysis Science and Technology |
Volume | 5 |
Issue number | 7 |
DOIs | |
Publication status | Published or Issued - 1 Jul 2015 |
Externally published | Yes |
ASJC Scopus subject areas
- Catalysis