Pathogenic memory type Th2 cells in allergic inflammation

Yusuke Endo, Kiyoshi Hirahara, Ryoji Yagi, Damon J. Tumes, Toshinori Nakayama

Research output: Contribution to journalReview articlepeer-review

101 Citations (Scopus)


Immunological memory is a hallmark of adaptive immunity. Memory CD4 T helper (Th) cells are central to acquired immunity, and vaccines for infectious diseases are developed based on this concept. However, memory Th cells also play a critical role in the pathogenesis of various chronic inflammatory diseases, including asthma. We refer to these populations as 'pathogenic memory Th cells.' Here, we review recent developments highlighting the functions and characteristics of several pathogenic memory type Th2 cell subsets in allergic inflammation. Also discussed are the similarities and differences between pathogenic memory Th2 cells and recently identified type 2 innate lymphoid cells (ILC2), focusing on cytokine production and phenotypic profiles.

Original languageEnglish
Pages (from-to)69-78
Number of pages10
JournalTrends in Immunology
Issue number2
Publication statusPublished or Issued - Feb 2014


  • Asthma
  • IL-5
  • ILC2
  • Memory Th2 diversity
  • Pathogenic T cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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