PEGylated superparamagnetic iron oxide nanoparticles labeled with 68Ga as a PET/MRI contrast agent: a biodistribution study

Afsaneh Lahooti; Saeed Sarkar; Hamidreza Saligheh Rad; Amir Gholami; Sahar Nosrati; Robert N. Muller; Sophie Laurent; Cordula Grüttner; Parham Geramifar; Hassan Yousefnia; Mohammad Mazidi; Saeed Shanehsazzadeh

doi:10.1007/s10967-016-5058-0

PEGylated superparamagnetic iron oxide nanoparticles labeled with ⁶⁸Ga as a PET/MRI contrast agent: a biodistribution study

Afsaneh Lahooti, Saeed Sarkar, Hamidreza Saligheh Rad, Amir Gholami, Sahar Nosrati, Robert N. Muller, Sophie Laurent, Cordula Grüttner, Parham Geramifar, Hassan Yousefnia, Mohammad Mazidi, Saeed Shanehsazzadeh

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

The purpose of this study is to evaluate the biodistribution of polyethylene glycol (PEG) coated superparamagnetic iron oxide nanoparticles radiolabeled with ⁶⁸Ga in normal mice after intravenous administration of this probe. Three mice were sacrificed at specific time intervals. The biodistribution data revealed high uptake by liver and spleen (60.62 and 12.65 %ID/g at 120 min post injection for liver and spleen, respectively). The clearance of other organs was fast. These results suggest that ⁶⁸Ga-PEG-SPIONs has magnificent capabilities for applying in (PET-MRI) as a theranostic agent for detection of liver and spleen malignancies.

Original language	English
Pages (from-to)	769-774
Number of pages	6
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume	311
Issue number	1
DOIs	https://doi.org/10.1007/s10967-016-5058-0
Publication status	Published or Issued - 1 Jan 2017
Externally published	Yes

Keywords

Biodistribution
Cancer
Ga
Liver
Spleen
Superparamagnetic iron oxide nanoparticles (SPION)

ASJC Scopus subject areas

Analytical Chemistry
Nuclear Energy and Engineering
Radiology Nuclear Medicine and imaging
Pollution
Spectroscopy
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

Access to Document

10.1007/s10967-016-5058-0

Cite this

Lahooti, A., Sarkar, S., Saligheh Rad, H., Gholami, A., Nosrati, S., Muller, R. N., Laurent, S., Grüttner, C., Geramifar, P., Yousefnia, H., Mazidi, M., & Shanehsazzadeh, S. (2017). PEGylated superparamagnetic iron oxide nanoparticles labeled with ⁶⁸Ga as a PET/MRI contrast agent: a biodistribution study. Journal of Radioanalytical and Nuclear Chemistry, 311(1), 769-774. https://doi.org/10.1007/s10967-016-5058-0

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title = "PEGylated superparamagnetic iron oxide nanoparticles labeled with 68Ga as a PET/MRI contrast agent: a biodistribution study",

abstract = "The purpose of this study is to evaluate the biodistribution of polyethylene glycol (PEG) coated superparamagnetic iron oxide nanoparticles radiolabeled with 68Ga in normal mice after intravenous administration of this probe. Three mice were sacrificed at specific time intervals. The biodistribution data revealed high uptake by liver and spleen (60.62 and 12.65 %ID/g at 120 min post injection for liver and spleen, respectively). The clearance of other organs was fast. These results suggest that 68Ga-PEG-SPIONs has magnificent capabilities for applying in (PET-MRI) as a theranostic agent for detection of liver and spleen malignancies.",

keywords = "Biodistribution, Cancer, Ga, Liver, Spleen, Superparamagnetic iron oxide nanoparticles (SPION)",

author = "Afsaneh Lahooti and Saeed Sarkar and {Saligheh Rad}, Hamidreza and Amir Gholami and Sahar Nosrati and Muller, {Robert N.} and Sophie Laurent and Cordula Gr{\"u}ttner and Parham Geramifar and Hassan Yousefnia and Mohammad Mazidi and Saeed Shanehsazzadeh",

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doi = "10.1007/s10967-016-5058-0",

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Lahooti, A, Sarkar, S, Saligheh Rad, H, Gholami, A, Nosrati, S, Muller, RN, Laurent, S, Grüttner, C, Geramifar, P, Yousefnia, H, Mazidi, M & Shanehsazzadeh, S 2017, 'PEGylated superparamagnetic iron oxide nanoparticles labeled with ⁶⁸Ga as a PET/MRI contrast agent: a biodistribution study', Journal of Radioanalytical and Nuclear Chemistry, vol. 311, no. 1, pp. 769-774. https://doi.org/10.1007/s10967-016-5058-0

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T1 - PEGylated superparamagnetic iron oxide nanoparticles labeled with 68Ga as a PET/MRI contrast agent

T2 - a biodistribution study

AU - Lahooti, Afsaneh

AU - Sarkar, Saeed

AU - Saligheh Rad, Hamidreza

AU - Gholami, Amir

AU - Nosrati, Sahar

AU - Muller, Robert N.

AU - Laurent, Sophie

AU - Grüttner, Cordula

AU - Geramifar, Parham

AU - Yousefnia, Hassan

AU - Mazidi, Mohammad

AU - Shanehsazzadeh, Saeed

PY - 2017/1/1

Y1 - 2017/1/1

N2 - The purpose of this study is to evaluate the biodistribution of polyethylene glycol (PEG) coated superparamagnetic iron oxide nanoparticles radiolabeled with 68Ga in normal mice after intravenous administration of this probe. Three mice were sacrificed at specific time intervals. The biodistribution data revealed high uptake by liver and spleen (60.62 and 12.65 %ID/g at 120 min post injection for liver and spleen, respectively). The clearance of other organs was fast. These results suggest that 68Ga-PEG-SPIONs has magnificent capabilities for applying in (PET-MRI) as a theranostic agent for detection of liver and spleen malignancies.

AB - The purpose of this study is to evaluate the biodistribution of polyethylene glycol (PEG) coated superparamagnetic iron oxide nanoparticles radiolabeled with 68Ga in normal mice after intravenous administration of this probe. Three mice were sacrificed at specific time intervals. The biodistribution data revealed high uptake by liver and spleen (60.62 and 12.65 %ID/g at 120 min post injection for liver and spleen, respectively). The clearance of other organs was fast. These results suggest that 68Ga-PEG-SPIONs has magnificent capabilities for applying in (PET-MRI) as a theranostic agent for detection of liver and spleen malignancies.

KW - Biodistribution

KW - Cancer

KW - Ga

KW - Liver

KW - Spleen

KW - Superparamagnetic iron oxide nanoparticles (SPION)

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