@article{a50d09af1169441ead136ed59648d7b9,
title = "Peri-prostatic adipose tissue: the metabolic microenvironment of prostate cancer",
abstract = "Emerging data have linked certain features of clinical prostate cancer (PCa) to obesity and, more specifically, increased adiposity. Whereas the large number of clinical studies and meta-analyses that have explored the associations between PCa and obesity have shown considerable variability, particularly in relation to prostate cancer risk, there is an accumulating weight of evidence consistently linking obesity to greater aggressiveness of disease. In probing this association mechanistically, it has been posited that peri-prostatic adipose tissue (PPAT), a significant component of the prostate microenvironment, may be a critical source of fatty acids and other mitogens and thereby influences PCa pathogenesis and progression. Notably, several recent studies have identified secreted factors from both PPAT and PCa that potentially mediate the two-way communication between these intimately linked tissues. In the present review, we summarize the available literature regarding the relationship between PPAT and PCa, including the potential biological mediators of that relationship, and explore emerging areas of interest for future research endeavours.",
keywords = "adipocytes, obesity, peri-prostatic adipose tissue, prostate cancer, tumour microenvironment",
author = "Nassar, {Zeyad D.} and Aref, {Adel T.} and Dushan Miladinovic and Mah, {Chui Yan} and Raj, {Ganesh V.} and Hoy, {Andrew J.} and Lisa Butler",
note = "Funding Information: Lisa M. Butler and Andrew J. Hoy acknowledge grant support from The Movember Foundation/Prostate Cancer Foundation of Australia (MRTA3). Zeyad D. Nassar is supported by the Freemason's Foundation Centre for Men's Health at the University of Adelaide and an Early Career Fellowship from the National Health and Medical Research Council of Australia (ID 1138648); Adel T. Aref is supported by an International PhD Scholarship from the University of Adelaide and the Freemason's Foundation Centre for Men's Health at the University of Adelaide; Chui Yan Mah is supported by a MPhil Scholarship from the University of Adelaide and the Freemason's Foundation Centre for Men's Health at the University of Adelaide; Ganesh V. Raj is the Paul Peters endowed chair of Urology and is supported by grants from the Department of Defense, Cancer Prevention Research Institute of Texas, the National Institutes of Health, the John and Mimi Cole Foundation and the Thompson family foundation; Andrew J. Hoy is supported by a Helen and Robert Ellis Postdoctoral Research Fellowship from the Sydney Medical School Foundation and funding from the University of Sydney; Lisa M. Butler is supported by a Future Fellowship from the Australian Research Council (FT130101004). Funding Information: Lisa M. Butler and Andrew J. Hoy acknowledge grant support from The Movember Foundation/Prostate Cancer Foundation of Australia (MRTA3). Zeyad D. Nassar is supported by the Freemason{\textquoteright}s Foundation Centre for Men{\textquoteright}s Health at the University of Adelaide and an Early Career Fellowship from the National Health and Medical Research Council of Australia (ID 1138648); Adel T. Aref is supported by an International PhD Scholarship from the University of Adelaide and the Freemason{\textquoteright}s Foundation Centre for Men{\textquoteright}s Health at the University of Adelaide; Chui Yan Mah is supported by a MPhil Scholarship from the University of Adelaide and the Freemason{\textquoteright}s Foundation Centre for Men{\textquoteright}s Health at the University of Adelaide; Ganesh V. Raj is the Paul Peters endowed chair of Urology and is supported by grants from the Department of Defense, Cancer Prevention Research Institute of Texas, the National Institutes of Health, the John and Mimi Cole Foundation and the Thompson family foundation; Andrew J. Hoy is supported by a Helen and Robert Ellis Postdoctoral Research Fellowship from the Sydney Medical School Foundation and funding from the University of Sydney; Lisa M. Butler is supported by a Future Fellowship from the Australian Research Council (FT130101004). Publisher Copyright: {\textcopyright} 2018 The Authors BJU International {\textcopyright} 2018 BJU International Published by John Wiley & Sons Ltd",
year = "2018",
month = may,
doi = "10.1111/bju.14173",
language = "English",
volume = "121",
pages = "9--21",
journal = "BJU International",
issn = "1464-4096",
publisher = "Wiley-Blackwell",
}