Periodontal tissue engineering

Saso Ivanovski, P. Mark Bartold, Stan Gronthos, Dietmar W. Hutmacher

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


The periodontium is composed of the tissues supporting and investing the tooth. One of the major goals of periodontal therapy is to encourage regeneration of tissues that have been destroyed as a result of periodontal disease. Bone grafting materials have been used to replace the alveolar bone lost within the periodontal defect, with the rationale being that this would facilitate new attachment formation to the adjacent root surface. Guided tissue regeneration (GTR) uses biocompatible barrier membranes to enable selective cellular recolonisation of periodontal defects. For successful periodontal regeneration via tissue engineering, the engineered tissues should have sufficient biomechanical strength, architectural properties, and space-maintaining ability. Several preclinical trials have shown that bone marrow-derived mesenchymal stem cells (BMMSCs) have the capacity to promote periodontal regeneration through enhanced generation of cementum, periodontal ligament, alveolar bone, and neovascularisation. The use of decellularised matrices as a biologic scaffold is gaining increasing attention in regenerative medicine.

Original languageEnglish
Title of host publicationTissue Engineering and Regeneration in Dentistry
Subtitle of host publicationCurrent Strategies
PublisherWiley Blackwell
Number of pages21
ISBN (Electronic)9781119282181
ISBN (Print)9781118741108
Publication statusPublished or Issued - 1 Nov 2016


  • Alveolar bone
  • Bone grafting
  • Bone marrow-derived mesenchymal stem cells
  • Guided tissue regeneration
  • Periodontal therapy
  • Regenerative medicine
  • Tissue engineering

ASJC Scopus subject areas

  • Dentistry(all)

Cite this