Pharmacogenomics of response to statin treatment and susceptibility to statin-induced adverse drug reactions in Asians: A scoping review

Hui Yin Yow, Sharina Hamzah, Nusaibah Abdul Rahim, Vijayaprakash Suppiah

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Background: Statins are the most widely used lipid-lowering agents for patients with hyperlipidemia. However, interindividual variations in efficacy and risk of adverse drug reactions to statin treatment have been widely reported. Ethnicity is well known to be one of the contributing factors to this variation, particularly among Asians. Objectives: To identify genetic variants associated with statin treatment responses among Asian populations with a focus on four commonly prescribed statins: atorvastatin, rosuvastatin, simvastatin, and pravastatin. Methods: A literature search was conducted in Medline and Embase databases. Studies published from 2008 to 2021 were included. The title and abstract of each article were screened by two reviewers and verified by another two reviewers. Data charted include information on authors, year of study, study population, statin studied, gene studied, study findings, and data of significant statistical value. Results: A total of 35 articles were included from the 1,939 original studies related to treatment efficacy and 5 articles out of the 284 original studies related to adverse effects. Genetic variants in transmembrane transporters, cytochrome P450 isoenzymes, and apolipoproteins are the most extensively studied among Asian populations, with a main focus on ethnic Chinese. However, Asia consists of genetically different populations, and the results of this review indicated that there is a paucity of studies on other ethnic groups within Asia. Conclusions: Considering the ethnicity of patients could provide a potential value to personalized medicine in statin therapy.

Original languageEnglish
Pages (from-to)95-114
Number of pages20
JournalAsian Biomedicine
Volume17
Issue number3
DOIs
Publication statusPublished or Issued - 1 Jun 2023
Externally publishedYes

Keywords

  • HMG-CoA reductase inhibitors
  • HMG-CoA statins
  • cholesterol
  • myotoxicity
  • pharmacogenomics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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