Phosphate starvation promotes swarming motility and cytotoxicity of Pseudomonas aeruginosa

Manjeet Bains; Lucía Fernández; Robert E.W. Hancock

doi:10.1128/AEM.01015-12

Phosphate starvation promotes swarming motility and cytotoxicity of Pseudomonas aeruginosa

Manjeet Bains, Lucía Fernández, Robert E.W. Hancock

Research output: Contribution to journal › Article › peer-review

89 Citations (Scopus)

Abstract

We investigated the transcriptional responses of Pseudomonas aeruginosa under phosphate-deficient (0.2 mM) conditions compared to phosphate sufficiency (1 mM). This elicited enormous transcriptional changes in genes related to phosphate acquisition, quorum sensing, chemotaxis, toxin secretion, and regulation. This dysregulation also led to increased virulence-associated phenotypes, including swarming motility and cytotoxicity.

Original language	English
Pages (from-to)	6762-6768
Number of pages	7
Journal	Applied and Environmental Microbiology
Volume	78
Issue number	18
DOIs	https://doi.org/10.1128/AEM.01015-12
Publication status	Published or Issued - Sept 2012
Externally published	Yes

ASJC Scopus subject areas

Biotechnology
Food Science
Applied Microbiology and Biotechnology
Ecology

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abstract = "We investigated the transcriptional responses of Pseudomonas aeruginosa under phosphate-deficient (0.2 mM) conditions compared to phosphate sufficiency (1 mM). This elicited enormous transcriptional changes in genes related to phosphate acquisition, quorum sensing, chemotaxis, toxin secretion, and regulation. This dysregulation also led to increased virulence-associated phenotypes, including swarming motility and cytotoxicity.",

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AB - We investigated the transcriptional responses of Pseudomonas aeruginosa under phosphate-deficient (0.2 mM) conditions compared to phosphate sufficiency (1 mM). This elicited enormous transcriptional changes in genes related to phosphate acquisition, quorum sensing, chemotaxis, toxin secretion, and regulation. This dysregulation also led to increased virulence-associated phenotypes, including swarming motility and cytotoxicity.

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JO - Applied and Environmental Microbiology

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Phosphate starvation promotes swarming motility and cytotoxicity of Pseudomonas aeruginosa

Abstract

ASJC Scopus subject areas

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