Polyphénols extraits de petits fruits et déclin cognitif lié à l’âge : résultats de l’étude Neurophenols.

Aging is characterized by memory deficits, associated with brain plasticity impairment. The age-related cognitive decline has been evidenced both in animals and human. Polyphenols from berries, were suggested to modulate cerebral plasticity and cognitive processes. The Neurophenols project developed a polyphenol-rich mix extracted from grape and blueberry (PEGB), with high concentrations of flavonoids and objectified its beneficial effect on the age-related cognitive decline.
At the preclinical level, in mice, hippocampal-dependent learning and memory alterations linked to aging are recovered by a PEGB consumption via the diet. The PEGB supplementation in aged mice, also restore the expression level of some genes marker of synaptic plasticity and neurogenesis, processes underlying memory performances.
These promising results in aged mice provide positive arguments on the benefits of PEGB on memory during human aging. An interventional study on the effect of PEGB on memory of elderly was also conducted as part of the Neurophenols project.