Population Genomics of Cardiometabolic Traits: Design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium

Tina Shah; Jorgen Engmann; Caroline Dale; Sonia Shah; Jon White; Claudia Giambartolomei; Stela McLachlan; Delilah Zabaneh; Alana Cavadino; Chris Finan; Andrew Wong; Antoinette Amuzu; Ken Ong; Tom Gaunt; Michael V. Holmes; Helen Warren; Teri Louise Davies; Fotios Drenos; Jackie Cooper; Reecha Sofat; Mark Caulfield; Shah Ebrahim; Debbie A. Lawlor; Philippa J. Talmud; Steve E. Humphries; Christine Power; Elina Hypponen; Marcus Richards; Rebecca Hardy; Diana Kuh; Nicholas Wareham; Yoav Ben-Shlomo; Ian N. Day; Peter Whincup; Richard Morris; Mark W J Strachan; Jacqueline Price; Meena Kumari; Mika Kivimaki; Vincent Plagnol; Frank Dudbridge; John C. Whittaker; Juan P. Casas; Aroon D. Hingorani

doi:10.1371/journal.pone.0071345

Population Genomics of Cardiometabolic Traits: Design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium

Tina Shah, Jorgen Engmann, Caroline Dale, Sonia Shah, Jon White, Claudia Giambartolomei, Stela McLachlan, Delilah Zabaneh, Alana Cavadino, Chris Finan, Andrew Wong, Antoinette Amuzu, Ken Ong, Tom Gaunt, Michael V. Holmes, Helen Warren, Teri Louise Davies, Fotios Drenos, Jackie Cooper, Reecha SofatMark Caulfield, Shah Ebrahim, Debbie A. Lawlor, Philippa J. Talmud, Steve E. Humphries, Christine Power, Elina Hypponen, Marcus Richards, Rebecca Hardy, Diana Kuh, Nicholas Wareham, Yoav Ben-Shlomo, Ian N. Day, Peter Whincup, Richard Morris, Mark W J Strachan, Jacqueline Price, Meena Kumari, Mika Kivimaki, Vincent Plagnol, Frank Dudbridge, John C. Whittaker, Juan P. Casas, Aroon D. Hingorani

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Abstract

Substantial advances have been made in identifying common genetic variants influencing cardiometabolic traits and disease outcomes through genome wide association studies. Nevertheless, gaps in knowledge remain and new questions have arisen regarding the population relevance, mechanisms, and applications for healthcare. Using a new high-resolution custom single nucleotide polymorphism (SNP) array (Metabochip) incorporating dense coverage of genomic regions linked to cardiometabolic disease, the University College-London School-Edinburgh-Bristol (UCLEB) consortium of highly-phenotyped population-based prospective studies, aims to: (1) fine map functionally relevant SNPs; (2) precisely estimate individual absolute and population attributable risks based on individual SNPs and their combination; (3) investigate mechanisms leading to altered risk factor profiles and CVD events; and (4) use Mendelian randomisation to undertake studies of the causal role in CVD of a range of cardiovascular biomarkers to inform public health policy and help develop new preventative therapies.

Original language	English
Article number	e71345
Journal	PloS one
Volume	8
Issue number	8
DOIs	https://doi.org/10.1371/journal.pone.0071345
Publication status	Published or Issued - 20 Aug 2013

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Shah, T., Engmann, J., Dale, C., Shah, S., White, J., Giambartolomei, C., McLachlan, S., Zabaneh, D., Cavadino, A., Finan, C., Wong, A., Amuzu, A., Ong, K., Gaunt, T., Holmes, M. V., Warren, H., Davies, T. L., Drenos, F., Cooper, J., ... Hingorani, A. D. (2013). Population Genomics of Cardiometabolic Traits: Design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium. PloS one, 8(8), Article e71345. https://doi.org/10.1371/journal.pone.0071345

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title = "Population Genomics of Cardiometabolic Traits: Design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium",

abstract = "Substantial advances have been made in identifying common genetic variants influencing cardiometabolic traits and disease outcomes through genome wide association studies. Nevertheless, gaps in knowledge remain and new questions have arisen regarding the population relevance, mechanisms, and applications for healthcare. Using a new high-resolution custom single nucleotide polymorphism (SNP) array (Metabochip) incorporating dense coverage of genomic regions linked to cardiometabolic disease, the University College-London School-Edinburgh-Bristol (UCLEB) consortium of highly-phenotyped population-based prospective studies, aims to: (1) fine map functionally relevant SNPs; (2) precisely estimate individual absolute and population attributable risks based on individual SNPs and their combination; (3) investigate mechanisms leading to altered risk factor profiles and CVD events; and (4) use Mendelian randomisation to undertake studies of the causal role in CVD of a range of cardiovascular biomarkers to inform public health policy and help develop new preventative therapies.",

author = "Tina Shah and Jorgen Engmann and Caroline Dale and Sonia Shah and Jon White and Claudia Giambartolomei and Stela McLachlan and Delilah Zabaneh and Alana Cavadino and Chris Finan and Andrew Wong and Antoinette Amuzu and Ken Ong and Tom Gaunt and Holmes, {Michael V.} and Helen Warren and Davies, {Teri Louise} and Fotios Drenos and Jackie Cooper and Reecha Sofat and Mark Caulfield and Shah Ebrahim and Lawlor, {Debbie A.} and Talmud, {Philippa J.} and Humphries, {Steve E.} and Christine Power and Elina Hypponen and Marcus Richards and Rebecca Hardy and Diana Kuh and Nicholas Wareham and Yoav Ben-Shlomo and Day, {Ian N.} and Peter Whincup and Richard Morris and Strachan, {Mark W J} and Jacqueline Price and Meena Kumari and Mika Kivimaki and Vincent Plagnol and Frank Dudbridge and Whittaker, {John C.} and Casas, {Juan P.} and Hingorani, {Aroon D.}",

note = "Funding Information: The authors have the following interests. John C Whittaker is an employee of GlaxoSmithKline. This study was partly funded by Du Pont Pharma, Wilmington, USA, Bayer plc (Unrestricted Investigator Led Grant) and Pfizer plc (Unrestricted Investigator Led Grant). There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors. ",

year = "2013",

month = aug,

day = "20",

doi = "10.1371/journal.pone.0071345",

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volume = "8",

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issn = "1932-6203",

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Shah, T, Engmann, J, Dale, C, Shah, S, White, J, Giambartolomei, C, McLachlan, S, Zabaneh, D, Cavadino, A, Finan, C, Wong, A, Amuzu, A, Ong, K, Gaunt, T, Holmes, MV, Warren, H, Davies, TL, Drenos, F, Cooper, J, Sofat, R, Caulfield, M, Ebrahim, S, Lawlor, DA, Talmud, PJ, Humphries, SE, Power, C, Hypponen, E, Richards, M, Hardy, R, Kuh, D, Wareham, N, Ben-Shlomo, Y, Day, IN, Whincup, P, Morris, R, Strachan, MWJ, Price, J, Kumari, M, Kivimaki, M, Plagnol, V, Dudbridge, F, Whittaker, JC, Casas, JP & Hingorani, AD 2013, 'Population Genomics of Cardiometabolic Traits: Design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium', PloS one, vol. 8, no. 8, e71345. https://doi.org/10.1371/journal.pone.0071345

TY - JOUR

T1 - Population Genomics of Cardiometabolic Traits

T2 - Design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium

AU - Shah, Tina

AU - Engmann, Jorgen

AU - Dale, Caroline

AU - Shah, Sonia

AU - White, Jon

AU - Giambartolomei, Claudia

AU - McLachlan, Stela

AU - Zabaneh, Delilah

AU - Cavadino, Alana

AU - Finan, Chris

AU - Wong, Andrew

AU - Amuzu, Antoinette

AU - Ong, Ken

AU - Gaunt, Tom

AU - Holmes, Michael V.

AU - Warren, Helen

AU - Davies, Teri Louise

AU - Drenos, Fotios

AU - Cooper, Jackie

AU - Sofat, Reecha

AU - Caulfield, Mark

AU - Ebrahim, Shah

AU - Lawlor, Debbie A.

AU - Talmud, Philippa J.

AU - Humphries, Steve E.

AU - Power, Christine

AU - Hypponen, Elina

AU - Richards, Marcus

AU - Hardy, Rebecca

AU - Kuh, Diana

AU - Wareham, Nicholas

AU - Ben-Shlomo, Yoav

AU - Day, Ian N.

AU - Whincup, Peter

AU - Morris, Richard

AU - Strachan, Mark W J

AU - Price, Jacqueline

AU - Kumari, Meena

AU - Kivimaki, Mika

AU - Plagnol, Vincent

AU - Dudbridge, Frank

AU - Whittaker, John C.

AU - Casas, Juan P.

AU - Hingorani, Aroon D.

N1 - Funding Information: The authors have the following interests. John C Whittaker is an employee of GlaxoSmithKline. This study was partly funded by Du Pont Pharma, Wilmington, USA, Bayer plc (Unrestricted Investigator Led Grant) and Pfizer plc (Unrestricted Investigator Led Grant). There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

PY - 2013/8/20

Y1 - 2013/8/20

N2 - Substantial advances have been made in identifying common genetic variants influencing cardiometabolic traits and disease outcomes through genome wide association studies. Nevertheless, gaps in knowledge remain and new questions have arisen regarding the population relevance, mechanisms, and applications for healthcare. Using a new high-resolution custom single nucleotide polymorphism (SNP) array (Metabochip) incorporating dense coverage of genomic regions linked to cardiometabolic disease, the University College-London School-Edinburgh-Bristol (UCLEB) consortium of highly-phenotyped population-based prospective studies, aims to: (1) fine map functionally relevant SNPs; (2) precisely estimate individual absolute and population attributable risks based on individual SNPs and their combination; (3) investigate mechanisms leading to altered risk factor profiles and CVD events; and (4) use Mendelian randomisation to undertake studies of the causal role in CVD of a range of cardiovascular biomarkers to inform public health policy and help develop new preventative therapies.

AB - Substantial advances have been made in identifying common genetic variants influencing cardiometabolic traits and disease outcomes through genome wide association studies. Nevertheless, gaps in knowledge remain and new questions have arisen regarding the population relevance, mechanisms, and applications for healthcare. Using a new high-resolution custom single nucleotide polymorphism (SNP) array (Metabochip) incorporating dense coverage of genomic regions linked to cardiometabolic disease, the University College-London School-Edinburgh-Bristol (UCLEB) consortium of highly-phenotyped population-based prospective studies, aims to: (1) fine map functionally relevant SNPs; (2) precisely estimate individual absolute and population attributable risks based on individual SNPs and their combination; (3) investigate mechanisms leading to altered risk factor profiles and CVD events; and (4) use Mendelian randomisation to undertake studies of the causal role in CVD of a range of cardiovascular biomarkers to inform public health policy and help develop new preventative therapies.

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U2 - 10.1371/journal.pone.0071345

DO - 10.1371/journal.pone.0071345

M3 - Article

C2 - 23977022

AN - SCOPUS:84882672302

SN - 1932-6203

VL - 8

JO - PloS one

JF - PloS one

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M1 - e71345

ER -

Population Genomics of Cardiometabolic Traits: Design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium

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