Pregnancy

Georgina Irish, Shilpanjali Jesudason

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Major physiological adaptive changes to renal hemodynamics, and glomerular and tubular function occurs with pregnancy. This chapter discusses pregnancy in women with chronic kidney failure at all stages. Clinical decision-making in this high-risk cohort is focused mainly on risk assessment for maternal and fetal outcomes, with very limited evidence regarding interventions. The number of pregnancies in patients receiving dialysis reported in the literature is increasing over time, although they remain rare. The safety of kidney biopsy in pregnancy is contentious. The impact of primary renal disease varies depending on the specific disease and the severity of kidney dysfunction. Women planning pregnancy should cease smoking, commence folic acid and vitamins, exchange teratogenic medications for pregnancy-safe options, and address relevant comorbidities including infection, anemia, and diabetes. Controlling hypertension before and during pregnancy is essential.

Original languageEnglish
Title of host publicationEvidence-Based Nephrology, Second Edition
Subtitle of host publicationVolumes 1,2
Publisherwiley
Pages444-460
Number of pages17
Volume1
ISBN (Electronic)9781119105954
ISBN (Print)9781119105923
DOIs
Publication statusPublished or Issued - 1 Jan 2022
Externally publishedYes

Keywords

  • Chronic kidney failure
  • Dialysis
  • Hypertension
  • Kidney biopsy
  • Pregnancy
  • Renal disease

ASJC Scopus subject areas

  • General Medicine

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