TY - JOUR
T1 - Prevalence of coronary artery disease across the Framingham risk categories
T2 - Coronary artery calcium scoring and MSCT coronary angiography
AU - Nucifora, Gaetano
AU - Schuijf, Joanne D.
AU - van Werkhoven, Jacob M.
AU - Jukema, J. Wouter
AU - Djaberi, Roxana
AU - Scholte, Arthur J.H.A.
AU - de Roos, Albert
AU - Schalij, Martin J.
AU - van der Wall, Ernst E.
AU - Bax, Jeroen J.
N1 - Funding Information:
Conflict of interest and financial disclosures: Gaetano Nucifora is financially supported by the European Association of Percutaneous Cardiovascular Interventions. Jacob M. van Werkhoven is financially supported by the Netherlands Society of Cardiology. Jeroen J. Bax has research grants from Biotronik, BMS medical imaging, Boston Scientific, Edwards Lifesciences, GE Healthcare, Medtronic, and St. Jude Medical. Martin J. Schalij has research grants from Biotronik, Boston Scientific, and Medtronic.
PY - 2009
Y1 - 2009
N2 - Background: Non-invasive assessment of subclinical atherosclerosis by means of coronary artery calcium scoring (CACS) and multi-slice computed tomography (MSCT) coronary angiography could improve patients' risk stratification. However, data relating observations on CACS and MSCT coronary angiography to traditional risk assessment are scarce. Methodsand Results: In 314 consecutive outpatients (54 ± 13 years, 56% males) without known CAD, CACS and 64-slice MSCT coronary angiography were performed. According to the Framingham risk score (FRS), 51% of patients were at low, 24% at intermediate and 25% at high risk, respectively. MSCT angiograms showing atherosclerosis were classified as showing obstructive (≥50% luminal narrowing) CAD or not. Both CACS and MSCT coronary angiography showed a high prevalence of normal coronary arteries in low FRS patients (70% and 61%, respectively). An increase in the prevalence of CACS >400 (4% low vs 19% intermediate vs 36% high), CAD (39% low vs 79% intermediate vs 91% high), and obstructive CAD (15% low vs 43% intermediate vs 58% high) was observed across the FRS categories (P < .0001 for all comparisons). Conclusions: A strong positive relationship exists between FRS and the prevalence and extent of atherosclerosis. Especially in intermediate FRS patients, CACS and MSCT coronary angiography provide useful information on the presence of subclinical atherosclerosis.
AB - Background: Non-invasive assessment of subclinical atherosclerosis by means of coronary artery calcium scoring (CACS) and multi-slice computed tomography (MSCT) coronary angiography could improve patients' risk stratification. However, data relating observations on CACS and MSCT coronary angiography to traditional risk assessment are scarce. Methodsand Results: In 314 consecutive outpatients (54 ± 13 years, 56% males) without known CAD, CACS and 64-slice MSCT coronary angiography were performed. According to the Framingham risk score (FRS), 51% of patients were at low, 24% at intermediate and 25% at high risk, respectively. MSCT angiograms showing atherosclerosis were classified as showing obstructive (≥50% luminal narrowing) CAD or not. Both CACS and MSCT coronary angiography showed a high prevalence of normal coronary arteries in low FRS patients (70% and 61%, respectively). An increase in the prevalence of CACS >400 (4% low vs 19% intermediate vs 36% high), CAD (39% low vs 79% intermediate vs 91% high), and obstructive CAD (15% low vs 43% intermediate vs 58% high) was observed across the FRS categories (P < .0001 for all comparisons). Conclusions: A strong positive relationship exists between FRS and the prevalence and extent of atherosclerosis. Especially in intermediate FRS patients, CACS and MSCT coronary angiography provide useful information on the presence of subclinical atherosclerosis.
KW - Calcium score
KW - Coronary artery disease
KW - Framingham risk score
KW - MSCT coronary angiography
KW - Risk stratification
UR - http://www.scopus.com/inward/record.url?scp=68049129742&partnerID=8YFLogxK
U2 - 10.1007/s12350-009-9059-z
DO - 10.1007/s12350-009-9059-z
M3 - Article
C2 - 19219520
AN - SCOPUS:68049129742
SN - 1071-3581
VL - 16
SP - 368
EP - 375
JO - Journal of Nuclear Cardiology
JF - Journal of Nuclear Cardiology
IS - 3
ER -