Principles and application of an in vivo swine assay for the determination of arsenic bioavailability in contaminated matrices

Matthew Rees; Lloyd Sansom; Allan Rofe; Albert L. Juhasz; Euan Smith; John Weber; Ravi Naidu; Tim Kuchel

doi:10.1007/s10653-008-9237-y

Principles and application of an in vivo swine assay for the determination of arsenic bioavailability in contaminated matrices

Matthew Rees, Lloyd Sansom, Allan Rofe, Albert L. Juhasz, Euan Smith, John Weber, Ravi Naidu, Tim Kuchel

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

The assessment of arsenic (As) bioavailability from contaminated matrices is a crucial parameter for reducing the uncertainty when estimating exposure for human health risk assessment. In vivo assessment of As utilising swine is considered an appropriate model for human health risk assessment applications as swine are remarkably similar to humans in terms of physiology and As metabolism. While limited in vivo As bioavailability data is available in the literature, few details have been provided regarding technical considerations for performing in vivo assays. This paper describes, with examples, surgical, experimental design and analytical issues associated with performing chronic and acute in vivo swine assays to determine As bioavailability in contaminated soil and food.

Original language	English
Pages (from-to)	167-177
Number of pages	11
Journal	Environmental Geochemistry and Health
Volume	31
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1007/s10653-008-9237-y
Publication status	Published or Issued - 2009
Externally published	Yes

Keywords

Arsenic
Bioavailability
In vivo
Swine

ASJC Scopus subject areas

Environmental Engineering
Environmental Chemistry
Water Science and Technology
General Environmental Science
Geochemistry and Petrology

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10.1007/s10653-008-9237-y

Cite this

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title = "Principles and application of an in vivo swine assay for the determination of arsenic bioavailability in contaminated matrices",

abstract = "The assessment of arsenic (As) bioavailability from contaminated matrices is a crucial parameter for reducing the uncertainty when estimating exposure for human health risk assessment. In vivo assessment of As utilising swine is considered an appropriate model for human health risk assessment applications as swine are remarkably similar to humans in terms of physiology and As metabolism. While limited in vivo As bioavailability data is available in the literature, few details have been provided regarding technical considerations for performing in vivo assays. This paper describes, with examples, surgical, experimental design and analytical issues associated with performing chronic and acute in vivo swine assays to determine As bioavailability in contaminated soil and food.",

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author = "Matthew Rees and Lloyd Sansom and Allan Rofe and Juhasz, {Albert L.} and Euan Smith and John Weber and Ravi Naidu and Tim Kuchel",

note = "Funding Information: Acknowledgements This research was funded through the Australian Research Council Linkage Grant Scheme, Grant number LP0347301. In vivo assays were approved and conducted according to application No. 17/02 of the Institute for Medical and Veterinary Science Animal Ethics Committee. The authors would like to acknowledge the support of the Centre for Environmental Risk Assessment and Remediation (University of South Australia), Centre for Pharmaceutical Studies (University of South Australia), and the Institute for Medical and Veterinary Science for this research.",

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AU - Sansom, Lloyd

AU - Rofe, Allan

AU - Juhasz, Albert L.

AU - Smith, Euan

AU - Weber, John

AU - Naidu, Ravi

AU - Kuchel, Tim

N1 - Funding Information: Acknowledgements This research was funded through the Australian Research Council Linkage Grant Scheme, Grant number LP0347301. In vivo assays were approved and conducted according to application No. 17/02 of the Institute for Medical and Veterinary Science Animal Ethics Committee. The authors would like to acknowledge the support of the Centre for Environmental Risk Assessment and Remediation (University of South Australia), Centre for Pharmaceutical Studies (University of South Australia), and the Institute for Medical and Veterinary Science for this research.

PY - 2009

Y1 - 2009

N2 - The assessment of arsenic (As) bioavailability from contaminated matrices is a crucial parameter for reducing the uncertainty when estimating exposure for human health risk assessment. In vivo assessment of As utilising swine is considered an appropriate model for human health risk assessment applications as swine are remarkably similar to humans in terms of physiology and As metabolism. While limited in vivo As bioavailability data is available in the literature, few details have been provided regarding technical considerations for performing in vivo assays. This paper describes, with examples, surgical, experimental design and analytical issues associated with performing chronic and acute in vivo swine assays to determine As bioavailability in contaminated soil and food.

AB - The assessment of arsenic (As) bioavailability from contaminated matrices is a crucial parameter for reducing the uncertainty when estimating exposure for human health risk assessment. In vivo assessment of As utilising swine is considered an appropriate model for human health risk assessment applications as swine are remarkably similar to humans in terms of physiology and As metabolism. While limited in vivo As bioavailability data is available in the literature, few details have been provided regarding technical considerations for performing in vivo assays. This paper describes, with examples, surgical, experimental design and analytical issues associated with performing chronic and acute in vivo swine assays to determine As bioavailability in contaminated soil and food.

KW - Arsenic

KW - Bioavailability

KW - In vivo

KW - Swine

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IS - SUPPL. 1

ER -

Principles and application of an in vivo swine assay for the determination of arsenic bioavailability in contaminated matrices

Abstract

Keywords

ASJC Scopus subject areas

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