TY - JOUR
T1 - Progression and reversibility of stretch induced atrial remodeling
T2 - Characterization and clinical implications
AU - Thanigaimani, Shivshankar
AU - McLennan, Emma
AU - Linz, Dominik
AU - Mahajan, Rajiv
AU - Agbaedeng, Thomas A.
AU - Lee, Geoffrey
AU - Kalman, Jonathan M.
AU - Sanders, Prashanthan
AU - Lau, Dennis H.
N1 - Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2017/11
Y1 - 2017/11
N2 - Atrial fibrillation (AF) is the most common sustained arrhythmia and across the developed nations, it contributes to increasing hospitalizations and healthcare burden. Several comorbidities and risk factors including hypertension, heart failure, obstructive sleep apnoea and obesity are known to play an important role in the initiation and perpetuation of AF and atrial stretch or dilatation may play a central mechanistic role. The impact of atrial stretch in the development of AF can vary dependent on the underlying disease. This review focuses on understanding the substrate for AF in conditions of acute and chronic stretch and in the presence of common co-morbidities or risk factors through the review of findings in both animal and human studies. Additionally, the reversibility of atrial remodeling following stretch release will also be discussed. Identification of clinical conditions associated with increased atrial stretch as well as the treatment or prevention of these conditions may help to prevent AF progression and improve sinus rhythm maintenance.
AB - Atrial fibrillation (AF) is the most common sustained arrhythmia and across the developed nations, it contributes to increasing hospitalizations and healthcare burden. Several comorbidities and risk factors including hypertension, heart failure, obstructive sleep apnoea and obesity are known to play an important role in the initiation and perpetuation of AF and atrial stretch or dilatation may play a central mechanistic role. The impact of atrial stretch in the development of AF can vary dependent on the underlying disease. This review focuses on understanding the substrate for AF in conditions of acute and chronic stretch and in the presence of common co-morbidities or risk factors through the review of findings in both animal and human studies. Additionally, the reversibility of atrial remodeling following stretch release will also be discussed. Identification of clinical conditions associated with increased atrial stretch as well as the treatment or prevention of these conditions may help to prevent AF progression and improve sinus rhythm maintenance.
UR - http://www.scopus.com/inward/record.url?scp=85026371339&partnerID=8YFLogxK
U2 - 10.1016/j.pbiomolbio.2017.07.010
DO - 10.1016/j.pbiomolbio.2017.07.010
M3 - Review article
C2 - 28734850
AN - SCOPUS:85026371339
SN - 0079-6107
VL - 130
SP - 376
EP - 386
JO - Progress in Biophysics and Molecular Biology
JF - Progress in Biophysics and Molecular Biology
ER -